Design, synthesis and in vitro cytotoxicity evaluation of 5-(2-carboxyethenyl)isatin derivatives as anticancer agents

From Anilines to Isatins: Oxidative Palladium‐Catalyzed Double Carbonylation of CH Bonds

“…[4] Many isatin derivatives exhibit a broad range of biological activities such as anticancer, [5] anticonvulsant, [6] antifungal, [7] anti-HIV, [8] and antiinflammatory, [9] and others.…”

“…Isatin (indoline-2,3-dione) is a well-known natural product which is present in bioactive compounds, synthetic intermediates, and pharmaceuticals. [4] Many isatin derivatives exhibit a broad range of biological activities such as anticancer, [5] anticonvulsant, [6] antifungal, [7] anti-HIV, [8] and antiinflammatory, [9] and others. [10] Although a number of methods have been established for the construction of such structures, the reported synthetic methods of isatins often require substrate pre-functionalization, multiple steps, and starting materials which are not readily available.…”

Synthesis of spiro-fused heterocyclic scaffolds through multicomponent reactions involving isatin

“…Substituted isatin analogues constitute valuable building blocks for potential pharmaceuticals with a wide range of biological properties such as antimicrobial, 4 antitumor, [5][6][7][8] antitubercular, [9][10] antimalaria, 11 anti-HIV, 12 and antibacterial. 13 Furthermore, isatin is a core constituent of many drugs.…”

Selected Pharmacological Applications of 1<sup>st</sup> Row Transition Metal Complexes: A review

“…K. Han, Y. Zhou, F. Liu et al were designed, synthesised and in vitro cytotoxicity evaluation of 5-(2-carboxyethenyl)isatin derivatives as anticancer agents [125]. Mohd Abdul Fatah Abdul Manan and et al were shown crystal structure and cytotoxicity of centrosymmetric copper(II) complex derived from S-methyldithiocarbazate with isatin [126]. Patitungkho S, Adsule S, Dandawate P and et al were shown anticancer property of Cu(II) complexes of isatin [127].…”