Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds

Pharmacological activities of Triazole analogues as antibacterial, antifungal, antiviral agents

“…Triazole is a five membered basic compound, containing two carbon and three nitrogen atoms having molecular formula C 2 H 3 N 3 . It forms a pair of isomeris [1][2][3][4][5][6] . The 1,2,3-triazole is measured to be the most stable compound in relationship to all other compounds possessing three adjacent nitrogen atoms.…”

Synthesis of 1,2,3-Triazole 5-Chloroisatin Derivatives via Copper-Catalyzed 1,3-Dipolar Cycloaddition Reactions

“…In fact, the orthogonal character vs. the reactivity of most functional groups, complete regioselectivity in favor of the 1,4-disustituted-1,2,3-triazole, mild reaction conditions, and easy installation of the required azide and terminal alkyne moieties in the reactive partners, render the metal-promoted version of the long-standing Huisgen 1,3-dipolar cycloaddition reaction the most prominent technique in the clickchemistry toolbox [9]. With applications ranging from material science to medicinal chemistry the 1,2,3-triazole core has been recognized as one of the most potent azoles with broad chemotherapeutic properties including antifungal [10], anticancer [11], antitubercular [12], antimalarial [13], anti-inflammatory [14], and antiviral [15] activities. Isatin and its derivatives are currently being considered as an important class of molecules, since many of them show diverse biological activities such as antiviral, anticancer [16][17][18][19], antibacterial [20,21] and anticorrosive [22,23] ones [24].…”

Synthesis and Biological Activities of 3-Alkyl-5-substituted 1,2,4-Triazole Derivatives

“…Azoles are the prominent type of compounds used for this purpose. 1,2,4,-Triazole and its derivatives are an important class of nitrogenous heterocyclic compounds which has been shown to possess a wide range of pharmacological properties such as antifungal 2,3 , antibacterial 4,5 , antimalarial 6 , antiinflammatory, anticonvulsant, antidepressant, antiviral and antitumor activities [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] . Therefore, 1,2,4-triazole derivatives have attracted considerable attention during the last few decades [22][23][24][25] .…”