“…In synthesis process, chlorokojic acid (2‐chloromethyl‐5‐hydroxy‐4 H ‐pyran‐4‐one, CKA) was obtained from commercially available kojic acid in a one‐step reaction. 2‐Substituted‐6‐(hydroxymethyl/chloromethyl)‐3‐hydroxy‐4 H ‐pyran‐4‐one (compounds 1 , 2 , 5 and 8 ) derivatives were synthesized with the reaction of appropriate substituted benzylpiperazine derivatives with KA or CKA and formaline at room temperature (Aytemir et al, ; Aytemir, Ozcelik, & Karakaya, ; Karakaya, Aytemir, Ozcelik, & Calis, ; Karakaya et al, ). Finally, Mannich bases of CKA reacted with piperidine or pyrrolidine moieties in the dimethylformamide (DMF) in presence of K 2 CO 3 to synthesize compounds with the structure of 2‐substituted‐3‐hydroxy‐6‐(piperidinylmethyl/pyrrolidinylmethyl)‐4 H ‐pyran‐4‐one (compounds 3 , 4 , 6 , 7 , 9 , and 10) (Karakaya et al, , ).…”