Design, synthesis and herbicidal activity of 5-cyclopropyl-N-phenylisoxazole-4-carboxamides

Chemical Evaluation, Phytotoxic Potential, and In Silico Study of Essential Oils from Leaves of Guatteria schomburgkiana Mart. and Xylopia frutescens Aubl. (Annonaceae) from the Brazilian Amazon

“…HPPD was selected as the target protein because it is the molecular target for compounds with postemergence herbicidal activity. In plants, the inhibition of HPPD results in the depletion of carotenoids, and the absence of chloroplast development in emerging foliar tissues results in necrosis and death [ 110 , 111 ]. The X-ray crystal structure of the HPPD protein (PDB: 6J63) was downloaded from the RCSB protein data bank.…”

Survey on the Recent Advances in 4-Hydroxyphenylpyruvate Dioxygenase (HPPD) Inhibition by Diketone and Triketone Derivatives and Congeneric Compounds: Structural Analysis of HPPD/Inhibitor Complexes and Structure–Activity Relationship Considerations

“…A series of 30 new isoxazole derivatives were designed by transforming the carbonyl bridge of the isoxaflutole molecule into the corresponding amide spacer (Figure ). The resulting compounds showed herbicidal activity possibly mediated by two different mechanisms of action that were characterized by no bleaching symptoms in Petri dish assays and evident bleaching ability in pre- and postemergence assays in greenhouse conditions. This evidence suggested a HPPD-independent mechanism of action in the first case, while a HPPD-dependent herbicidal activity was evoked in the second case.…”

Synthesis and Bioactivity Evaluation of Novel Thiochroman-4-One Derivatives Incorporating Carboxamide and 1, 3, 4-Thiadiazole Thioether Moieties

“…In our previous study, we disclosed a series of novel thiochroman-4-one derivatives (Figure 1) which showed moderate to good antibacterial and antifungal activities [11][12][13][14]. e carboxamide moiety, an important functional group in pesticide chemistry, had attracted more and more attention to the researchers due to its broad spectrum of pesticidal bioactivities, for example, antibacterial [15,16], antifungal [17,18], antiviral [19][20][21], insecticidal [22,23], and herbicidal [24] properties. Over the past few decades, many new pesticides containing carboxamide moiety, such as fluxapyroxad, penflufen, and isoflucypram, had been developed.…”