Design, synthesis and fungicidal activities evaluation of N-(thiazol-4-ylmethyl) benzenesulfonamide derivatives

Zheng, Suiping; Huang, Danling

doi:10.1007/s11696-022-02540-2

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“…The fungicidal activities of the above compounds to A. alternala, S. sclerotiorum, B. cinerea, and F. oxysporum were tested by the method described in our previous report. [22][23] Briefly, 0.5 cm mycelial plugs of the pathogens were prepared and transferred onto PDA plates supplemented with the indicated concentrations of the compounds. The same volumes of DMSO were used as a control.…”

Section: Bioactivity Assaymentioning

confidence: 99%

Structural Optimization, Fungicidal Activities Evaluation, DFT Study and Structure‐Activity Relationship of Dopamine Derivatives with Benzothiazole Fragment from Polyrhachis dives

Wang

Huang

Cheng

2023

Chemistry & Biodiversity

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In our previous work, two dopamine derivatives with benzothiazole fragment were isolated and identified from Polyrhachis dives (P. dives). Based on their characteristic structure, we used them as lead compound to carry out structural optimization and subsequent fungicidal evaluation. Here 20 dopamine derivatives with benzothiazole fragment were designed and synthesized by a facile method, and their structures were characterized by 1 H-NMR, 13 CNMR and HMRS. In bioassays, most of the title compounds possess potential fungicidal activities against Altenaia alternala (A. alternala) and Botrytis cinerea (B. cinerea). Especially, (E)-N-(2-(benzo[d]thiazol-6-yl)ethyl)-3-(ptolyl)acrylamide and (E)-N-(2-(benzo[d]thiazol-6-yl)ethyl)-3-(4-(trifluoromethyl)phenyl)acrylamide displayed 29.3 mg/L and 10.7 mg/L EC 50 value against A. alternala, respectively, which possessed equivalent fungicidal activities level to hymexazol.

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Section: Bioactivity Assaymentioning

confidence: 99%