Design, Synthesis and Evaluation of Difunctionalized 4-Hydroxybenzaldehyde Derivatives as Novel Cholinesterase Inhibitors

Yu, Liang; Cao, Rihui; Yi, Wei; Yan, Qin; Chen, Zhiyong; Ma, Lin; Song, Huacan

doi:10.1248/cpb.58.1216

Cited by 6 publications

(2 citation statements)

References 26 publications

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“…The solvents were dried and purified before use. The aldehyde used for the synthesis of porphyrins was synthesized by following the previously reported procedure .…”

Section: Methodsmentioning

confidence: 99%

Antimicrobial Photodynamic Efficiency of Novel Cationic Porphyrins towards Periodontal Gram‐positive and Gram‐negative Pathogenic Bacteria

Prasanth

Karunakaran

Paul

et al. 2013

Photochem & Photobiology

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The Gram-negative Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum are major causative agents of aggressive periodontal disease. Due to increase in the number of antibiotic-resistant bacteria, antimicrobial Photodynamic therapy (aPDT) seems to be a plausible alternative. In this work, photosensitization was performed on Gram-positive and Gram-negative bacteria in pure culture using new-age cationic porphyrins, namely mesoimidazolium-substituted porphyrin derivative (ImP) and pyridinium-substituted porphyrin derivative (PyP). The photophysical properties of both the sensitizers including absorption, fluorescence emission, quantum yields of the triplet excited states and singlet oxygen generation efficiencies were evaluated in the context of aPDT application. The studied porphyrins exhibited high ability to accumulate into bacterial cells with complete penetration into early stage biofilms. As compared with ImP, PyP was found to be more effective for photoinactivation of bacterial strains associated with periodontitis, without any signs of dark toxicity, owing to its high photocytotoxicity.

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“…The solvents were dried and purified before use. The aldehyde used for the synthesis of porphyrins was synthesized by following the previously reported procedure .…”

Section: Methodsmentioning

confidence: 99%

Antimicrobial Photodynamic Efficiency of Novel Cationic Porphyrins towards Periodontal Gram‐positive and Gram‐negative Pathogenic Bacteria

Prasanth

Karunakaran

Paul

et al. 2013

Photochem & Photobiology

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“…4-HBA is a structural isomer of salicylaldehyde with one hydroxyl (-OH) group at the para position of the phenolic ring. Several studies have suggested that 4-HBA is an active candidate for improving insulin resistance and inhibiting cholinesterase 16 , 17 . However, the therapeutic effects of 4-HBA on acute wound healing have not been determined.…”

Section: Introductionmentioning

confidence: 99%

4-Hydroxybenzaldehyde accelerates acute wound healing through activation of focal adhesion signalling in keratinocytes

Kang

Han

Kim

et al. 2017

Sci Rep

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4-Hydroxybenzaldehyde (4-HBA) is a naturally occurring benzaldehyde and the major active constituent of Gastrodia elata. While recent studies have demonstrated metabolic effects of 4-HBA, little is known about the physiological role of 4-HBA in acute wound healing. Here, we investigated the effects and mechanisms of 4-HBA on acute wound healing. Using an in vitro approach, we found that 4-HBA significantly promoted keratinocyte cell migration and invasion by increasing focal adhesion kinase and Src activity. In addition, 4-HBA treatment also promoted wound healing and re-epithelialization in an in vivo excision wound animal model. Combination treatment with 4-HBA and platelet-derived growth factor subunit B homodimer showed synergistic effects in promoting wound healing. Taken together, our results demonstrated that treatment with 4-HBA promoted keratinocyte migration and wound healing in mouse skin through the Src/mitogen-activated protein kinase pathway. Therefore, 4-HBA could be a candidate therapeutic agent with the potential to promote acute wound healing.

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ChemInform Abstract: Design, Synthesis and Evaluation of Difunctionalized 4‐Hydroxybenzaldehyde Derivatives as Novel Cholinesterase Inhibitors.

Cao

et al. 2011

ChemInform

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Design, Synthesis and Evaluation of Difunctionalized 4-Hydroxybenzaldehyde Derivatives as Novel Cholinesterase Inhibitors

Cited by 6 publications

References 26 publications

Antimicrobial Photodynamic Efficiency of Novel Cationic Porphyrins towards Periodontal Gram‐positive and Gram‐negative Pathogenic Bacteria

Antimicrobial Photodynamic Efficiency of Novel Cationic Porphyrins towards Periodontal Gram‐positive and Gram‐negative Pathogenic Bacteria

4-Hydroxybenzaldehyde accelerates acute wound healing through activation of focal adhesion signalling in keratinocytes

ChemInform Abstract: Design, Synthesis and Evaluation of Difunctionalized 4‐Hydroxybenzaldehyde Derivatives as Novel Cholinesterase Inhibitors.

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