2021
DOI: 10.1590/1678-9199-jvatitd-2020-0066
|View full text |Cite
|
Sign up to set email alerts
|

Design, synthesis, and evaluation of Bothrops venom serine protease peptidic inhibitors

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
4
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 9 publications
(4 citation statements)
references
References 22 publications
(7 reference statements)
0
4
0
Order By: Relevance
“…However, mAbs failed to neutralize the toxins of B. alternatus and B. neuwiedi venoms [ 41 ]. Da Silva et al [ 49 ] designed two synthetic peptides that inhibited SVSPs of B. jararaca crude venom and the purified serine protease Batroxobin, but not human trypsin, which is a serine protease. Undoubtedly, such peptides are a promising therapeutic tool for improving the treatment of SBE caused by Bothrops species.…”
Section: Discussionmentioning
confidence: 99%
“…However, mAbs failed to neutralize the toxins of B. alternatus and B. neuwiedi venoms [ 41 ]. Da Silva et al [ 49 ] designed two synthetic peptides that inhibited SVSPs of B. jararaca crude venom and the purified serine protease Batroxobin, but not human trypsin, which is a serine protease. Undoubtedly, such peptides are a promising therapeutic tool for improving the treatment of SBE caused by Bothrops species.…”
Section: Discussionmentioning
confidence: 99%
“…Sousa et al [ 39 ] compared the composition and reactivity with multispecific Bothrops antivenom (SAB) of venoms collected from six species of Bothrops , Bothropoides and Rhinocerophis snakes, and found that P-III SVMPs are the most antigenic toxins in the venoms of snakes from the Bothrops complex, while class P-I SVMPs, SVSPs and PLA 2 s reacted with SAB in lower levels. Silva et al [ 40 , 41 ] discovered that the antivenom targeting Bothrops venom has limitations in addressing local effects such as hemorrhage and neutralizing SVSPs. However, they observed that supplementing the antivenom with a serine protease inhibitor can enhance its overall efficacy.…”
Section: Discussionmentioning
confidence: 99%
“…Ongoing efforts to develop alternative therapeutics for the treatment of SBE have targeted the inhibition of major toxic components of snake venom. In this regard, inhibitors of sPLA2, [60–62] SVMPs [63–69] and SVSPs [70,71] have shown varying degrees of promise at protecting against the lethal effects of some medically important snake venoms in preclinical studies. Given that some enzymatically active snake venom toxins are dependent on metal ions as cofactors, small‐molecule metal chelators have also been investigated in the search of novel treatment [72–74] .…”
Section: Toward Novel Small‐molecule Snake Antivenom Therapeuticsmentioning
confidence: 99%