Design, synthesis and evaluation of structurally diverse ortho-acylphenol-diindolylmethane hybrids as anticancer agents

Abstract

A highly efficient synthesis of structurally diverse ortho-acylphenol–diindolylmethane hybrids 3 using carboxylic acid-activated chromones as versatile synthetic building blocks is reported here for the first time, through 1,4-nucleophilic addition and followed by a decarboxylation and pyrone ring opening reaction process.

Chemistry of 3-cyanoacetyl indoles: synthesis, reactions and applications: a recent update

“…[20][21][22][23][24] 3-Substituted indoles such as cyanoacetyl indoles (CAIs) are nitrogen-heterocyclic compounds which are versatile starting materials utilized for the construction of a wide variety of molecules containing indole moieties in organic synthesis. A large portion of these molecules exhibits promising biological activities such as against nicotinic acetylcholine receptors and prostaglandin-mediated disease, 25 antimicrobial, 26 antifungal, 27 anti-inammatory and analgesic activities, 28 against prophylaxis and angiogenesis, 29 anticancer 30,31 and acts as inhibitors of JNK. 32 Up to date, two review articles have been published based on the synthesis and reactions of 3-cyanoacetyl indoles.…”