Abstract:22 Novel pyridazin-3-ones have been designed for antihepatitis B virus (HBV) activity by structural modifications of 3711 which is capsid assembly modulator. Structure of the target compounds were confirmed by elemental analysis and spectroscopic data including X-ray studies. Among them, the compound having piperazine moiety showed notable inhib-itory activity on secretion of HBV DNA and HBeAg which is comparable to that of AT-130. The preliminary structure-activity relationships (SARs) of the newly synthesize… Show more
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