Design, Synthesis and Evaluation of Aurone and Indanone Derivatives as Novel Antibacterial Agents
Baoxing Xie,
Haiqing Zhao,
Ailin Hu
et al.
Abstract:Aurones and indanones were proved to be potential antibacterial agents in our recent work. Based on strategy of bioisosterism and diene insertion, a series of aurone and indanone derivatives were designed and synthesized, then submitted to the antibacterial activity evaluation on C. albicans, E. coli and S. aureus. According to the results, nineteen of thirty synthesized compounds had inhibitory activity against at least one bacterium. The minimum value of MIC activity was 62.5 µM (A2, B1, B3, B4, B8, C6, D1, … Show more
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