Design, synthesis, and cytotoxicity of ibuprofen-appended benzoxazole analogues against human breast adenocarcinoma

Abstract

A library of novel Ibuprofen appended Benzoxazole analogues (7a-l) were synthesized by a series of nitration, reduction and condensation cyclization reactions and screened for their invitro anticancer activity against human...

Design and synthesis of Meldrum's acid based 7-azaindole anchored 1,2,3-triazole hybrids as anticancer agents

“…The Autodock Vina integrated PyRx virtual tool was employed for the present study. [56][57][58] The crystal structures of epidermal growth factor receptor (EGFR) (PDB ID: 2J6M) 49 and myeloid cell leukemia-1 (Mcl-1) (PDB ID: 5FDO) 50 were retrieved from Protein Data Bank (https://www.rcsb.org). The ligand was sketched in ChemDraw Professional 16.0 and saved in MDL file format.…”