Design, synthesis and characterization of some novel 4-aminoantipyrine derivatives and evaluation of their  activity as analgesic agents

Muhammad‐Ali, Munther Abduljaleel; Mohammad, A. Rashid; Hameed, Basim Jasim; Shaheed, Dhurgham Q.

doi:10.32383/appdr/144130

Cited by 1 publication

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“…Among all synthesized four compounds exhibited excellent activity comparable to ibuprofen and aspirin at the similar dosages [54] . [55] . The synthesized compounds containing main essentials pharmacophore for binding to the benzodiazepine receptor and possess good anticonvulsant activity [56] .…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Synthesis, Evaluation and Pharmacological action of Oxadiazole derivatives

Meher¹,

Nayak²,

Singh³

et al. 2020

J Pharmacogn Phytochem

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Impacted numerous drug discovery programs including-muscarinic antagonists, benzodiazepine receptor partial agonists, Dopamine transporters, antirhinovirals, growth hormone secretagogues, 5-HT antagonists, antispasmodics. Heterocyclic compounds possess diverse biological properties that have led to intense study and research of these compounds. One of these compounds is Oxadiazole which has been found to exhibit various pharmacological activities. 1, 3, 4-oxadiazole having heterocyclic nucleus is a novel molecule which attract the chemist to search for a new therapeutic molecule. 1,3,4-oxadizole exhibited a wide range of biological activities which includes antibacterial, anti-tubercular, anticonvulsant, hypoglycemic, anti-allergic, enzyme inhibitor, vasodialatory, antifungal, cytotoxic, antiinflammatory, analgesic, hypolipidemic, anticancer, insecticidal, ulcerogenic activities etc. Out of the various derivative 2, 5-Disubstituted-1, 3, 4-oxadiazole is a widely exploited for various application. A large number of drugs used clinically have oxadiazole ring as a structural building block. The capacity of 1,3,4-oxadiazole nucleus to undergo variety of chemical reactions including electrophilic substitution, nucleophilic substitution, thermal and photochemical which make it medicinal backbone on which a number of potential molecules can be constructed. This review has basic information about 2, 5disubstituted-1, 3, 4-oxadiazole derivatives published in various journals for further development in the field. Oxadiazole derivatives are a class of heterocyclic compounds. The titled compounds were synthesized according to the procedures as given in the methodology. The reactions were monitored by TLC. The physical constants like melting point and solubility were determined for all the intermediates and final products. The compounds were further characterized by IR and 1H NMR and mass spectra. All the titled compounds were evaluated for their Anticonvulsant, Anti-inflammatory, Antibacterial, Antitubercular and Antioxidant activity.

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Section: Anti-inflammatory Activitymentioning

confidence: 99%