Abstract:Inhibition of Helicobacter pylori urease is an effective method in the treatment of a number of gastrointestinal diseases in humans. This bacterium plays an important role in the pathogenesis of gastritis and peptic ulceration. Considering the presence of cysteine and N-arylacetamide derivatives in potent urease inhibitors, here, we designed hybrid derivatives of these pharmacophores. Therefore, cysteine -N-arylacetamide derivatives 5a-l were synthesized through simple nucleophilic reactions with good yield. I… Show more
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