Design, synthesis and biological investigation of certain pyrazole-3-carboxylic acid derivatives as novel carriers for nitric oxide

Convenient Synthesis, Characterization, Cytotoxicity and Toxicity of Pyrazole Derivatives

“…Many pyrazole derivatives have attracted considerable attention in the recent years for their diverse biological activities. [1][2][3][4][5][6] They are also acknowledged for their anticancer activities. [7][8][9] Celecoxib, sulfaphenazole, CDPPB, linazolac, mepiprazole, and rimonabant are some of the pyrazole-based drugs available today in the market ( Figure 1).…”

Microwave-Assisted Synthesis and Cytotoxicity Evaluation of Some Novel Pyrazole Containing Imidiazole, Pyrazole, Oxazole, Thiadiazole and Benzochromene derivatives

“…So it clearly underlies the urgent need for developing novel chemotherapeutic agents with more potent antitumor activities. Recently, pyrazole derivatives have attracted a great attention due to their several chemicals and pharmacological importance [1][2][3]. Moreover, many pyrazole derivatives exhibit a wide range of therapeutic activities including anticonvulsant [4], analgesic, anti-inflammatory [5][6][7], antimicrobial [8], anticoagulant activity [9], antioxidant [10], antiamoebic [11,12], Antidepressant [13], antihyperglycemic [14], antihistaminic [15], anti-viral [16], anti-HIV [17], and anticancer [18][19][20][21][22].…”

Synthesis and anti-bacterial activity of novel 1,3-pheylene-bis-N-acetyl- and N-phenylpyrazole derivatives

“…[9][10][11] For thus, pyrazole derivatives have attracted considerable attention in the recent years for their diverse biological activities. [12][13][14][15][16][17] In this paper, the novel 1,1'-(5,5'-(1,3-phenylene)bis(3-aryl-4,5-dihydro-1H-pyrazole-5,1-diyl))diethanone (5a-e) and 1,3-bis(1-phenyl-3-(aryl)-4,5-dihydro-1H-pyrazol-5-yl)benzene (6a-e) were synthesized in good yields and evaluated the antibacterial activities of compounds (5a-e) against some human pathogenic bacteria.…”