Design, synthesis, and biological evaluation of oxindole derivatives as antidepressive agents

[Et3NH][HSO4] catalyzed solvent‐free synthesis of new 1,2,3‐triazolidene‐indolinone derivatives

“…The arylidene‐indolinones were prepared by using harsh conditions and/or toxic reagents, for example, organic bases such as piperidine. [ 30 ] Et 2 NH, [ 31 ] pyrrolidine, [ 32 ] inorganic acids like HCl, [ 33 ] metal oxide clusters, [ 34 ] and Al 2 O 3. [ 35 ] Recent green methodologies involve microwave irradiation using methanol as solvent [ 36 ] and nano‐acid catalyst SBA‐Pr‐SO 3 H. [ 37 ] A scant of literature reported a use of ionic liquid for the synthesis of arylidene‐indolinones.…”

Selective C3-alkenylation of oxindole with aldehydes using heterogeneous CeO2 catalyst

“…Indoles, oxindoles, isatins, and their derivatives are relevant nitrogen-containing heterocycles widely distributed in natural products and pharmaceutical compounds [1]. Oxindole is used as a neurodepressant tryptophan metabolite and physiologically present in mammalian brain/blood, and can influence brain functions [2]. 3-Alkyledene-oxindole derivatives are medicinally important and exist in anticancer kinase inhibitors and anti-inflammatory drugs including Sunitinid and Tedinap, respectively [3][4][5].…”

Molecular Iodine-Mediated Ring Opening Reaction of Spiro-Epoxy Oxindoles with Electron Rich Arenes

“…3,3‐disubstituted 2‐oxindole and its derivatives have acquired more importance owing to their occurrence in numerous natural products and biologically active compounds . These compounds exhibits a wide range of biological activities such as anticancer agent, antimycobacterial agent, antidepressive agents, 5‐ht7 receptor antagonist activity, potential p53 activity modulators, antiproliferative activity and growth hormone secretagogues…”