Design, Synthesis and Biological Evaluation of Novel Anticancer Agent Sprio Indolone Compounds

Abstract

Indolone is a kind of natural product which was widely existed in the animal bodies and plants, which possess varieties of biological activities, such as anti-bacterial, anti-tumor, anti-aging and anti-anxiety activities. As we all known that many sprio compounds which containing hetero atom such as O, N, S have good biological activities. In this paper, a series of spiro indolone derivatives was design with the combination of indolone and sprio scaffold, 6 novel target compounds were synthesized in 3 or 4 steps in 6%-17% overall yield, which were characterized by1H NMR and their biological activities on tumor cells growth inhibition on human hepatoma cell HePG2 and human leukemia cell K562 by MTT method were evaluated.