Design, synthesis and biological evaluation of novel 2,4,6-trisubstituted quinazoline derivatives as potential antitumor agents

Design, Synthesis, Docking Studies and Molecular Dynamics Simulation of New 1,3,5‐Triazine Derivatives as Anticancer Agents Selectively Targeting Pancreatic Adenocarcinoma (Capan‐1)

“…[5][6][7][8][9][10][11][12] The 1,3,5-triazine ring has proven to be a successful framework for developing novel anticancer agents. [13] Several 2,4,6-trisubstiuted 1,3,5-triazine derivatives have demonstrated remarkable antitumor activities [14][15][16][17][18][19][20][21][22][23][24][25][26] and serve as templates for several of clinically used drugs and drug candidates, e. g., tretamine (Figure 1, 1) [27] is a drug used in chemotherapy, hexamethylmelamine (altretamine, HMM) (Figure 1, 2) and its hydroxylated analogue are clinically utilized for treatment of epithelial ovarian carcinoma. [28] A recently developed metformin derivative (Figure 1, 3) has been documented for its capability to inhibit the growth and metastasis of triplenegative breast cancer cells.…”