Design, synthesis, and biological evaluation of indolylidinepyrazolones as potential anti-bacterial agents

1H-Indole-3-carboxaldehyde: Synthesis and Reactions

“…However, some cases of Knoevenagel condensation of 1 have been carried out in the presence of acid such as hydrochloric acid and/ or acetic acid, for example, reaction of 1 with 2-thioxo-dihydro-pyrimidine-4,6-dione,82 indan-1,3-dione, 10H-anthracen-9-one [83] and/or 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one [84] yield Knoevenagel products 30a-d. (Scheme 21). A host of ammonia derivatives other than amines also form similar condensation products with indole aldehydes.…”

Pyrazolone-type compounds (part II): in vitro and in silico evaluation of antioxidant potential; structure–activity relationship

“…4 Such an outcome was triggered by the diversity of pyrazolone-based compounds and their richness in benecial biological virtues. 2,7 Pyrazolonecored derivatives mostly wield antimicrobial, [8][9][10][11][12][13] anticancer, 7,12,14,15 antiproliferative, 14,16 and antiinammatory potency, [17][18][19][20][21][22] but they were also identied as analgesics, 18,22,23 antivirals, [24][25][26] hypoglycaemics, 27 and antioxidants. 11,28,29 The utilisation of pyrazolone synthon produced numerous hybrid molecules acting as multitarget agents.…”

Pyrazole‐Clubbed Piperazinyl Urea Derivatives: Synthesis, Characterization and Antimicrobial Studies toward Generating an Antibiotic/Antifungal Resistance Sensor

“…[1][2][3] A literature survey revealed that many heterocyclic derivatives having pyrazole as core structure exhibiting a broad spectrum of approved biological activities such as antiinflammatory, antipyretic, gastric secretion stimulatory, antidepressant, antibacterial, antifilarial agents, HIV-1 non-nucleoside reverse transcriptase inhibitors and dual inhibitors of CCR5/ CXCR4 HIV entry. [4][5][6][7][8][9][10][11][12][13][14][15][16][17] Furthermore, this pharmacophore is occur in several well-known active drugs such as Rimonabant, Celecoxib, Tepoxalin, Viagra, Lonazolac, and Fipronil [18][19][20][21] which are enlisted among the most selling drugs albeit few have been retrieved from the market owing to the side effects. Moreover, the other applications of pyrazole derivatives were also well reported in the fields of fluorescence, agriculture, luminophores, and drug discovery.…”