Design, Synthesis and Biological Activity of the 4-Thioquinoline Derivative
Anna Bohdan,
Yanina Romanenko,
Mikhail Zavhorodnii
et al.
Abstract:One of the promising areas in the creation of bioregulators is the modeling of compounds that combine several pharmacophores. The design of new highly efficient and low-toxic cytoprotectors is largely based on the derivatives of nitrogen-containing heterocycles, and quinoline plays a significant role among these compounds. The researchers evaluated the toxicity of the tested compounds in silico, in vitro, and in vivo, which allowed determiningseveral factors that affect the level of toxic action of 4-thioquino… Show more
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