Design, Synthesis and Antifungal Activities of Novel Strobilurin Derivatives Containing Pyrimidine Moieties

Zhang, Xiang; Gao, Yanning; Liu, Huijun; Guo, Baoyuan; Wang, Huili

doi:10.5012/bkcs.2012.33.8.2627

Cited by 8 publications

(3 citation statements)

References 30 publications

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“…So far, about 20 strobilurin analogs have been isolated from basidiomycetes such as Oudemans iellamucida, Pterula sp., Xerula longipes, Mycena crocota, Favolaschia calocera and ascomycetes, for example Bolinea lutea (Malita, 2008). Fungicides belonging to this group are highly prized for strong activity, low toxicity to mammalian cells and environmentally sound (Zhang et al 2012).…”

Section: Strobilurin Fungicidesmentioning

confidence: 99%

Current possibilities and prospects of using fungicides in forestry

Okorski

Pszczółkowska

Oszako

et al. 2015

Forest Research Papers

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The possibility of using chemicals in European forestry is extremely limited due to the binding legal regulations and specific conditions concerning the market of plant protection products. This is reflected in the limited availability of active fungicides in forestry. Due to this limitation, practitioners using fungicides in forest nurseries and forest cultivation must have substantial knowledge of the biology of pathogens to ensure satisfactorily effective protection.The work presented here provides an overview of the currently recommended fungicides in Polish forestry as well as the mechanisms of interaction between the active substances and the pathogen, the plant and mycorrhizal fungi. The risk of fungicide resistance, which has been insufficiently explored in the context of forest pathogens, is also discussed in this paper.

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Section: Strobilurin Fungicidesmentioning

confidence: 99%

Current possibilities and prospects of using fungicides in forestry

Okorski

Pszczółkowska

Oszako

et al. 2015

Forest Research Papers

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“…[4][5][6][7] Their primary action mechanism is the inhibition of mitochondrial respiration. So far, thousands of analogues have been synthesized, [8][9][10][11][12][13] leading to more than 10 commercial products, such as including metominostrobin, azoxystrobin and so on ( Figure 1). However, their derivatives rarely have insecticidal activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Evaluation O-Benzyl Oxime-ether Derivatives Containing β-Methoxyacrylate Moiety for Insecticidal and Fungicidal Activities

Hu¹,

Luo²,

Wang³

et al. 2014

Bulletin of the Korean Chemical Society

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In attempt to lead compounds exhibiting both insecticidal and fungicidal activities, a series of O-benzyl oximeether derivatives were designed and synthesized by introducing β-methoxyacrylate pharmacophore into a scaffold. The insecticidal activity against Aphis fabae and the fungicidal activity against Erysiphe graminis were screened. The title compounds exhibited remarkable insecticidal and fungicidal activities. The most potent compound 6d was identified. Its insecticidal LC 50 against A. fabae is 6.4 mg/L, which is lower than that of chlorfenapyr (19.4 mg/L) and even close to the level of imidacloprid (4.8 mg/L). Its fungicidal EC 90 in preventive and curative treatment against E. graminis are 2.2 and 4.8 mg/L, respectively, which are lower than azoxystrobin (7.0 and 5.9 mg/L). These results indicate that compound 6d can be considered as a lead for further developing new O-benzyl oxime-ether typed candidates with both fungicidal and insecticidal activities.

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“…Its total yield is also below 30%. 8 In terms of route 3, sodium hydride, which is inflammable is involved, and high boiling point solvent NMP, i.e. N-methylpyrrolidone is also employed, which was prohibited by the European Union in 2003 as a toxic substance that affects fertility.…”

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confidence: 99%