Abstract:A new series of dihydro-1, 2-oxazole coumarin derivatives (SR1-SR10) was prepared using a multi-step reaction. The syntheses of intermediates coumarinyl chalcones and final compounds were characterized by IR, Mass, and 1 H NMR spectra. The final compound’s SR1-SR10 binding mode and its inhibitor susceptibility were studied by molecular docking with the receptor DNA gyrase B (PDB code: 5L3J). It is responsible for catalyzing changes during DNA replication and validated targets for antibacterial molecules. The d… Show more
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