Design, synthesis, and antibacterial activity of novel thiochromanone derivatives containing an acylhydrazone moiety

Synthesis and Bioactivity Evaluation of Novel Thiochroman-4-One Derivatives Incorporating Carboxamide and 1, 3, 4-Thiadiazole Thioether Moieties

“…As shown in Scheme 1, the key intermediates 2 and 4 were prepared according to our previously reported literature [11][12][13][14]16].…”

“…erefore, natural products can either be used directly in bacterial and fungal control or develop novel synthetic analogs with favorable biological properties. iochroman-4-one, an important natural product which is widely found in many plants, showed extensive bioactivities, including antifungal [8], herbicidal [9], insecticidal [10], and antibacterial [11][12][13][14] properties. In our previous study, we disclosed a series of novel thiochroman-4-one derivatives (Figure 1) which showed moderate to good antibacterial and antifungal activities [11][12][13][14].…”

“…iochroman-4-one, an important natural product which is widely found in many plants, showed extensive bioactivities, including antifungal [8], herbicidal [9], insecticidal [10], and antibacterial [11][12][13][14] properties. In our previous study, we disclosed a series of novel thiochroman-4-one derivatives (Figure 1) which showed moderate to good antibacterial and antifungal activities [11][12][13][14]. e carboxamide moiety, an important functional group in pesticide chemistry, had attracted more and more attention to the researchers due to its broad spectrum of pesticidal bioactivities, for example, antibacterial [15,16], antifungal [17,18], antiviral [19][20][21], insecticidal [22,23], and herbicidal [24] properties.…”