Design, synthesis and anti-diabetic activity of chromen-2-one derivatives

Fast and Efficient Green Procedure for the Synthesis of Benzo[5,6]chromene Derivatives and Their Sulfur Analogues in Water by Organocatalyst Potassium Phthalimide-N-oxyl

“…As indicated in Scheme 2, the reasonable elucidation for the incident of the proposed keto-enol tautomerization in the 13 C NMR spectra is on the basis of the appearance of the signal for C=O* of aryloyl at higher than 170 ppm and also in the 1 H NMR spectra, the presence or absence of C*-H or O*-H proton as a singlet. Due to tautomeric interchanges, which are ordinarily very fast processes, this signal appeared as a broad singlet.…”

“….0]undec-7-ene) in water or ethanol under stirring at room temperature to reflux conditions to produce the desired product in 26-43% yield (Table 1, entries [13][14][15][16][17]. As can be seen, the use of water as a solvent, enhanced the yield of the desired reaction.…”

“…4 Chromeneannulated frameworks belong to a major class of natural compounds, which are broadly found in alkaloids, flavonoids, 5 and edible fruits and vegetables. 6 Chromene structure moiety have occupied a significant place in drug research in recent years for their various pharmacological properties such as antioxidant, 7 anticoagulant, 8 anticancer, 9 antimicrobial, 10 antiviral, 11 antifungal, 12 antidiabetic, 13 antiallergenic, 14 antimalarial, 15 antirheumatic, 16 spasmolytic, and anti-anaphylactic 17 activities. Moreover, this moiety as chemically useful synthon is widely used in pigments, 18 laser dyes 19 and cosmetics.…”

2H/4H-Chromenes—A Versatile Biologically Attractive Scaffold

“…One of the essential structural features of 4H-ch to impart miscellaneous activity is the occurrence of the fold along the oxygen axis. The molecules containing 2H/4H-ch scaffold exhibit noteworthy potency, such as anticancer (Afifi et al, 2017a ; Halawa et al, 2017 ; Elshaflu et al, 2018 ; Elnaggar et al, 2019 ; Luque-Agudo et al, 2019 ), anticonvulsant (Rawat and Verma, 2016 ), antimicrobial (Suvarna et al, 2017 ; Mashhadinezhad et al, 2019 ), anticholinesterase (Tehrani et al, 2019 ), antidiabetic activities (Soni et al, 2019 ), antituberculosis (Zhao et al, 2020 ), and inhibitory activity against monoamine oxidase (MAO) (Takao et al, 2019 ).…”

Study on the Synthesis of Some (Un)Substituted 2-Amino-4-aryl-7-hydroxy-4H-chromene-3-carbonitriles in the Water Medium

“…These compounds function as the important pharmacophores, which are associated with a broad range of pharmacological activities. They are antimicrobial [11], hypolipidemic [12], anti-inflammatory [13,14], anti-proliferative [15], antioxidant [11,16], anticoagulant [17], and anti-leishmanial [18], antitumor [15], anti-diabetic [19], cytotoxicity [10,20], and anticancer [16,20] agents.…”