Abstract:Objective: Novel anticancer agents were designed to be synthesized considering Leucettamine B as a lead compound. Leucettamine B, which was isolated from a marine sponge, is a tyrosine-regulated inhibitor of kinase 1A (Dyrk1A), and has gained a lot of attention as a pharmacological target in malignant brain tumors. Method: 3-Phenyl-2thioxoimidazolidin-4-one 1 has been used for the synthesis of various fused phenylimidazo2,4]triazine 10-14, 20 and 21 as well as imidazo[1,2b][1,2,4]triazepine analogues 15 and 17… Show more
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