Design, synthesis, and analysis of macrobicyclic peptides for targeting the Gαi protein
Anna Pepanian,
F. Ayberk Binbay,
Dehua Pei
et al.
Abstract:Bicyclic peptides are important chemical tools that can function, for example, as bioactive ligands switching on/off signaling pathways mediated by guanine nucleotide‐binding proteins as bicycles are more broadly applicable. Despite their relevance in medicinal chemistry, the synthesis of such peptides is challenging, and the final yield is highly dependent on the chemical composition and physicochemical properties of the scaffold. We recently discovered novel, state‐specific peptide modulators targeting the G… Show more
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