Design, Synthesis and Activity Evaluation Against Drug‐Resistant Bacteria of 6’‐Amidine Modified Aminoglycoside Derivatives
Jianguo Xu,
Xiaomei Zhang,
Guoqiang Xu
et al.
Abstract:The issue of bacterial resistance has become a matter of significant concern globally, prompting extensive research into the development and clinical application of aminoglycoside antibiotics (AGAs) as a crucial antibacterial therapy. One of the primary mechanisms contributing to aminoglycoside antibiotic resistance is the action of aminoglycoside modifying enzymes (AMEs), which modify aminoglycoside antibiotics and consequently confer drug resistance. Chemical modification of the AME action site can eliminate… Show more
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