Design, syntheses, and structure–activity relationships of novel NPY Y5 receptor antagonists: 2-{3-Oxospiro[isobenzofuran-1(3H),4′-piperidin]-1′-yl}benzimidazole derivatives

Ogino, Yukiko; Ohtake, Norikazu; Nagae, Yoshikazu; Matsuda, Kenji; Moriya, M.; Suga, Tetsuya; Ishikawa, Makoto; Kanesaka, Maki; Mitobe, Yuko; Itô, Junko; Kanno, Toshio; Ishihara, Akane; Iwaasa, Hisashi; Ohe, Tomoyuki; Kanatani, Akio; Fukami, Tatsuki

doi:10.1016/j.bmcl.2008.08.018

Cited by 45 publications

(21 citation statements)

References 27 publications

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“…They are important intermediates in many organic reactions [6,7] and act as ligands to transition metals for modelling biological systems [8,9]. In addition, the treatment potency of benzimidazoles in diseases such as ischemia-reperfusion injury [10], hypertension [11], obesity [12] etc. have been recently reported.…”

Section: Introductionmentioning

confidence: 99%

Catalytic role of sodium dodecyl sulfate: Selective synthesis of 1, 2-disubstituted benzimidazoles in water

Ghosh

Mandal

2011

Catalysis Communications

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Section: Introductionmentioning

confidence: 99%

Catalytic role of sodium dodecyl sulfate: Selective synthesis of 1, 2-disubstituted benzimidazoles in water

Ghosh

Mandal

2011

Catalysis Communications

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“…ischemia-reperfusion injury (Ogino et al, 2008), hypertension (Shah, Sharma, Bansal, Bansal, & Singh, 2008), obesity (Ghosh & Mandal, 2011), etc. has been recently reported.…”

Section: Public Interest Statementmentioning

confidence: 99%

Polyethylene glycol (PEG-400): An efficient medium for the synthesis of 1,2-disubstituted benzimidazoles

et al. 2015

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“…This reaction provides a practical synthetic route for the preparation of triazole adamantanes with large steric hindrance to overcome the serious amantadine/rimantadine resistance of influenza viruses. Thionyl bis-triazole can also be employed to N-alkylate with alcohols to produce novel triazole derivatives [242,243]. Reaction between compound 170 and N,N -thionylditriazole 171 successfully afforded potential CYP26 inhibitor 1,2,4-triazole derivative 172 (Scheme 71) [244].…”

Section: N-alkylation With Alcoholsmentioning

confidence: 99%

Current Developments in the Syntheses of 1,2,4-Triazole Compounds

Zhang¹,

Damu²,

Cai³

et al. 2014

COC

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Heterocyclic 1,2,4-triazole derivatives possess unusually spacious potentiality as medicinal agents, agricultural chemicals, functional materials, ionic liquids, supramolecular catalysts as well as artificial enzymes and receptors for supramolecular recognition and biomimetic catalysis, and their various researches and developments have been being a quite rapidly developing and active highlight topic with an infinite space. Numerous efforts have been directed toward various types of possible applications of 1,2,4-triazole-based compounds and a lot of important progress has been made, especially their preparations have attracted increasing attention. This review systematically summarized the recent advances in the syntheses of 1,2,4-triazole derivatives, including: (1) Cyclizations to form triazole ring; (2) Transformations of heterocyclic compounds to construct triazole ring; (3) Substitutions on 1,2,4-triazole ring; (4) Structural modifications in side chains of 1,2,4-triazole ring. It was hoped that this review would be helpful for the design and development of highly efficient preparation of 1,2,4-triazole derivatives with various sorts and varieties of extensively potential applications in medicine, agriculture, chemistry, materials, supramolecular sciences and so on.

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Design, syntheses, and structure–activity relationships of novel NPY Y5 receptor antagonists: 2-{3-Oxospiro[isobenzofuran-1(3H),4′-piperidin]-1′-yl}benzimidazole derivatives

Cited by 45 publications

References 27 publications

Catalytic role of sodium dodecyl sulfate: Selective synthesis of 1, 2-disubstituted benzimidazoles in water

Catalytic role of sodium dodecyl sulfate: Selective synthesis of 1, 2-disubstituted benzimidazoles in water

Polyethylene glycol (PEG-400): An efficient medium for the synthesis of 1,2-disubstituted benzimidazoles

Current Developments in the Syntheses of 1,2,4-Triazole Compounds

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