Design, Syntheses and Biological Evaluations of Nonpeptidic Caspase 3 Inhibitors.

Abstract

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A new blue light-emitting terphenyl-bridged bisbenzimidazolium salts: Synthesis, crystal structure, and photophysical properties

“…Tetrakis(triphenylphosphine)palladium(0) was purchased from ABCR Chemical Ltd. 1,4-Dibromobenzene (1a) and 2,5-dibromotoluene (1b) were purchased from J&K Chemical Ltd. 1,2-Benzenediamine (3a), 3,4-diaminotoluene (3b), and other reagents were purchased from Sinopharm Chemical Reagent Co. Ltd. 4-Cyanophenylboronic acid was synthesized according to methods described in the literature [34]. Solvents were purified through conventional procedures prior to use.…”

Anti-proliferative and metastatic protease inhibitory activities of protoberberines: An in silico and in vitro approaches

“…Studies have demonstrated that ROS activates MMP-9 and cathepsin B to mediate the breakdown of extracellular matrix [5]. Caspases 3, a cysteinyl aspartate specific protease, is reported to play a key role in the regulation of apoptosis [6]. Therefore, inhibition of MMP-9 and cathepsin B activities and activation of caspase 3 activity represent a promising strategy in metastatic cancer therapy [7].…”

Berberine: A potential adjunct for the treatment of gastrointestinal cancers?

“…On the other hand, BBR inhibits cancer metastases by regulating matrix metalloproteinases (MMPs). 31 BBR affects many different cellular pathways through inhibition of cyclooxigenase2 transcriptional activity in human colon cancer cells, 24 inhibition of caspase-3 (major apoptosis effector), 32 topoisomerase I and II poisoning activity, 33 and interaction with nucleic acids, especially DNA (DNA triplex binder). 34 Several studies have also demonstrated that BBR can inhibit arylamin N-acetyltransferase (NAT) activity that is required for the metabolic conversion of arylamine carcinogens.…”