Design study on photoacoustic probe to detect prostate cancer using 3D Monte Carlo simulation and finite element method

El-Gohary, Sherif H.; Metwally, Mohamed K.; Eom, Seyoung; Jeon, Seong Gyu; Byun, Kyung Min; Kim, Tae‐Seong

doi:10.1007/s13534-014-0150-2

Cited by 32 publications

(17 citation statements)

References 15 publications

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“…1(a)), transurethral light delivery and US detection 55,60 ( Fig. 1(b)), as well as transurethral light delivery coupled with transrectal US detection.…”

Section: Pai Systems For Prostate Imagingmentioning

confidence: 97%

“…55 The human prostate is located beyond this penetration limit from the skin surface 56 ; therefore, human prostate PAI with an external light source is currently unfeasible. Fortunately, the feasibility of prostate PAI using endoscopic light delivery has been well demonstrated through phantom studies, 57,58 simulation studies, 55,59,60 and animal studies. 57,58 One of the major challenges of human prostate PAI is the delivery of the light source.…”

Section: Pai Systems For Prostate Imagingmentioning

confidence: 99%

“…61 Although transurethral US detection yielded optimal image quality in Monte Carlo simulations performed by Tang et al 60 (Figs. 2(c) and 2(g)) and El-Gohary et al, 55 a transrectal US transducer is more frequently used in urology. Urologists prefer a transrectal transducer because it is convenient for clinical practice.…”

Section: Pai Systems For Prostate Imagingmentioning

confidence: 99%

“…55,59,60 In transrectal light delivery, the light must penetrate through the rectum wall before it reaches the prostate. At the wavelength of 1000 nm, the rectal absorption and scattering coe±cients, a and s , are greater than those in the prostate by factors of 2 and 5, respectively.…”

Section: Transrectal Light Deliverymentioning

confidence: 99%

“…At the wavelength of 1000 nm, the rectal absorption and scattering coe±cients, a and s , are greater than those in the prostate by factors of 2 and 5, respectively. 55,66,67 Consequently, transrectal illumination su®ers from signi¯cant energy loss due to the severe light scattering in the rectum wall and is not ideal for in vivo wholeprostate imaging (Figs. 2(d) and 2(h)).…”

Section: Transrectal Light Deliverymentioning

confidence: 99%

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Photoacoustic imaging of prostate cancer

Yang

Xiang

2017

J. Innov. Opt. Health Sci.

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Photoacoustic imaging (PAI), also known as optoacoustic imaging, is a rapidly growing imaging modality with potential in medical diagnosis and therapy monitoring. This paper focuses on the techniques of prostate PAI and its potential applications in prostate cancer detection. Transurethral light delivery combined with transrectal ultrasound detection overcomes light scattering in the surrounding tissue and provides optimal photoacoustic signals while minimizing invasiveness. While label-free PAI based on endogenous contrast has promising potential for prostate cancer detection, exogenous contrast agents can further enhance the sensitivity and speci¯city of prostate cancer PAI. Further in vivo studies are required in order to achieve the translation of prostate PAI to clinical implementation. The minimal invasiveness, relatively low cost, high speci¯city and sensitivity, and real-time imaging capability are valuable advantages of PAI that may improve the current prostate cancer management in clinic.

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“…1(a)), transurethral light delivery and US detection 55,60 ( Fig. 1(b)), as well as transurethral light delivery coupled with transrectal US detection.…”

Section: Pai Systems For Prostate Imagingmentioning

confidence: 97%