Design Strategy for a Hydroxide-Triggered pH-Responsive Hydrogel as a Mucoadhesive Barrier to Prevent Metabolism Disorders

Tang, Rui‐Chian; Chen, Tzu-Chien; Lin, Feng‐Huei

doi:10.1021/acsami.1c17706

Cited by 12 publications

(14 citation statements)

References 38 publications

(60 reference statements)

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“…To mimic the intestinal environment, the syringe pumping rate is in accordance with the shear force produced during intestinal peristalsis as 1.8 μ N cm −1 . 16 The result in vitro showed that the mucoadhesive property of AC is better than alginate under such conditions with intestinal epithelioid cell line, IEC-6 [ Figs. 4(d) and 4(e) ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the material which formed intestinal coating has been proved to decrease the nutrition uptake. 16 Therefore, we aim to engineer the chemical properties of alginate for a longer retention time by investigating the microenvironment where the material attaches the mucus layer. The mucus layer mostly consists of mucin, a kind of glycoprotein with a free thiol group for oxidation–reduction reaction.…”

Section: Introductionmentioning

confidence: 99%

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Development of resveratrol with thiolated alginate as a supplement to prevent nonalcoholic fatty liver disease (NAFLD)

Chen

Tang

et al. 2022

APL Bioengineering

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Nowadays, nonalcoholic fatty liver disease is a common metabolic liver disease of all ages worldwide. However, current pharmacological and surgical treatments are accompanied with side effects and complications. EndoBarrier, a less invasive bariatric surgery, blocks the upper portion of the intestine to reduce nutrition absorption. To mimic the nutrient restriction effect of EndoBarrier, thiol-containing materials may bind to the thiol groups of the mucus with an enhanced mucoadhesive property. Here, we develop thiolated alginate with cysteine conjugation via an N-(3-dimethylaminopropyl)-N-ethylcarbodiimide/N-hydroxysuccinimide reaction. The alginate–cysteine (AC) exhibits excellent mucoadhesive properties and forms a physical barrier in the intestine to reduce absorption significantly, which was tested with both in vitro and in vivo mucoadhesive test and barrier function test. The nontoxicity property of AC was also proven with WST-1 and live and dead stain. In addition, AC demonstrates potent carrier properties of extending the release of resveratrol to improve the efficacy with the test of the transwell system in the release profile. In the long-term therapeutic evaluation, alginate cysteine with resveratrol (ACR) is orally administrated daily to mice with an methionine choline-deficient diet. The results of this in vivo study show that developed ACR could effectively alleviate fat degeneration in the liver and improve fat-related metabolic parameters in serum without hepatocellular damage and kidney dysfunction. In sum, AC was found to be mucoadhesive, reduce glucose absorption, alleviate inflammation, and decrease fatty degradation. This promising material exhibits the potential to be a supplement for nonalcoholic fatty liver disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of resveratrol with thiolated alginate as a supplement to prevent nonalcoholic fatty liver disease (NAFLD)

Chen

Tang

et al. 2022

APL Bioengineering

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“…Polysaccharides participate in many biological activities, such as cytoskeleton formation, energy metabolism, blood glucose regulation and immunity modulation, are biocompatible and biodegradable, and can be easily extracted, processed and modified. Polysaccharides extracted from plants (for example, alginate 105,106 , cellulose 107 , starch 108 , carrageenan 109 , pectin 110 , guar gum 109 , mannan 111 , glucomannan 112 and inulin 113 ), animals (for example, chitosan 101,114 , hyaluronate 5 and chondroitin sulfate 115 ) and microbes (for example, pullulan 116 and β-glucan 117 ) are being explored for oral drug delivery. Polysaccharide nanoparticle formulations can orally deliver small molecules, oligonucleotides, peptides and proteins 94 .…”

Section: Biological Materialsmentioning

confidence: 99%

Bioinspired oral delivery devices

et al. 2023

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Oral administration is a widespread and convenient drug delivery approach. However, oral delivery can be affected by the complex digestive tract environment, including irregular tissue morphology, the presence of digestive enzymes, mucus and mucosal barriers, and spatiotemporal variance in physiological parameters. These obstacles can prevent the oral delivery of many therapeutics. To overcome these challenges, oral delivery devices can be designed with bioinspired compositions, structures or functions to make more drugs available for oral administration. Various bioinspired oral delivery devices have been developed by harnessing biological materials and living microorganisms, or by imitating biological structures and functions. In this Review, we discuss the design and modification of bioinspired oral delivery devices, examining engineering strategies to target specific tissues and applications. We highlight how key bottlenecks in oral delivery can be addressed through bioinspired designs, concluding with an outlook on the remaining challenges towards the clinical translation of bioinspired oral delivery devices. SectionsIntroduction Naturally derived oral delivery devices Bioinspired oral delivery Target tissues Outlook

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“…Compared with traditional hydrogels, intelligent hydrogels can achieve multiple, variable, controllable and reversible changes in their shape and properties in a manner of space or time, thus greatly adapting to the complex application environment in vitro and in vivo. [37][38][39][40][41] Recently, various intelligent hydrogels, such as light-responsive hydrogels, [42][43][44][45][46] thermal-responsive hydrogels, [47][48][49][50][51] pH-responsive hydrogels, [52][53][54][55][56] ultrasound-responsive hydrogels, [57][58][59] ion-responsive hydrogels, [60][61][62] etc., have been developed and showed amazing biomedical applications. Among them, as a new class of intelligent hydrogels, ultrasound-responsive hydrogels have already exhibited irreplaceable application prospects.…”

Section: Introductionmentioning

confidence: 99%