Design, Spectroscopic Studies, DFT Calculations and Evaluation of Biological Activity of Novel 1,3-Benzoxazines Encompassing Isoniazid

Matada, Basavarajaiah Suliphuldevara; Yernale, Nagesh Gunavanthrao; Javeed, Mohammad

doi:10.1080/10406638.2021.2019062

Cited by 16 publications

(2 citation statements)

References 27 publications

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“…Compound 56 (Figure 9) exhibited significant antibacterial and antifungal effects against E. coli and A. flavus with MIC value 6.25 μg/ml that is better than standard drugs Gentamycin and Fluconazole respectively. Also, the compound 57 possess more potent anti‐TB activity (MIC value 1.56 μg/ml) than the standard drug ciprofloxacin [41] …”

Section: Biological Activities Of 13‐oxazine Derivativesmentioning

confidence: 99%

“…Also, the compound 57 possess more potent anti-TB activity (MIC value 1.56 μg/ml) than the standard drug ciprofloxacin. [41] Xu et al in 2022 reported chitin synthase inhibition and antifungal activities of spiro[benzoxazine-piperidin]-one derivatives. Compounds 58-61 (Figure 9) exhibited broad spectrum antifungal activities which were found to be equal to those of fluconazole and polyoyxin B.…”

Section: Anti-bacterial Activity Of 13-oxazine Derivativesmentioning

confidence: 99%

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1,3‐Oxazine as a Promising Scaffold for the Development of Biologically Active Lead Molecules

Gupta,

Saini,

Basavarajaiah

et al. 2023

ChemistrySelect

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Heterocyclic compounds form an important part of wide range of biologically active molecules. The heteroatom provides them specificity for various receptors. 1,3‐oxazine has been considered as a privileged scaffold in many medicinal chemistry applications. Compounds having 1,3‐oxazine moiety exhibit broad range of biological applications such as anticancer, antimicrobial, anti‐inflammatory, antiplatelet, antitubercular and alpha‐glucosidase inhibition activities. In this review, we consolidate the recent developments in the synthesis and biological activities of 1,3‐oxazine containing compounds. Also, the structure activity relationship (SAR) studies of different derivatives exhibiting several biological activities are summarized. Database such as Science direct, Pubmed and Google scholar were searched using keywords ‘1,3‐Oxazine’, ‘synthesis’, ‘derivatives’, and ‘biological activities’. The review would provide a lead for the development of competent candidates with 1,3‐oxazine moiety having broad range of applications in the treatment of several human disorders.

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Section: Biological Activities Of 13‐oxazine Derivativesmentioning

confidence: 99%

Section: Anti-bacterial Activity Of 13-oxazine Derivativesmentioning

confidence: 99%