Design Rules for the Nano‐Bio Interface of Nanodiamonds: Implications for siRNA Vectorization
Marek Kindermann,
Jitka Neburkova,
Eva Neuhoferova
et al.
Abstract:The enormous therapeutic potential of selective ribonucleic acid (RNA) interference has recently been manifested by the approval of several small interfering RNA (siRNA)‐based drugs. However, the efficacy of siRNA delivery is still limited, and an extensive search for alternative and highly effective delivery approaches is ongoing. With this aim, three generations of non‐viral vectors based on modified nanodiamonds (NDs) have been gradually developed in the past decade. They show great promise due to the negli… Show more
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