Design principles of sensory processing in cerebellum-like structures

Roberts, Patrick D.; Portfors, Christine V.

doi:10.1007/s00422-008-0217-1

Cited by 28 publications

(26 citation statements)

References 110 publications

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“…We propose that the need to cancel multiple frequencies requires independent frequency channels and multiple learning rules. Our results indicate that the precise timing of sensory or motor associated signals is a general function of parallel fibers of the cerebellum and related structures such as the ELL or the dorsal cochlear nucleus (Oertel and Young, 2004;Roberts and Portfors, 2008;Tzounopoulos and Kraus, 2009). The local circuitry and dynamics (synaptic and intrinsic) of the PF target varies, however, so as to implement the appropriate adaptive filter required for each system.…”

Section: Discussionmentioning

confidence: 68%

“…The EOD of mormyrids consists of brief pulses with long and variable interpulse intervals and the EOD command nucleus sends corollary discharge to the EGp that, as in A. leptorhynchus, provides feedback to the ELL. This circuit is also used as an adaptive filter to cancel redundant sensory input (Roberts and Bell, 2000;Roberts and Portfors, 2008;Sawtell and Williams, 2008), and theoretical studies have implicated the mormyrid PFs in conveying the precise timing of the EOD corollary discharge to ELL neurons (Roberts and Bell, 2000). The PF-SP cell synapse analog in the mormyrid ELL obeys an anti-Hebbian spike timing-dependent plasticity (STDP) rule (Bell et al, 1997) instead of correlative burst-induced rules.…”

Section: Discussionmentioning

confidence: 99%

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Frequency-Tuned Cerebellar Channels and Burst-Induced LTD Lead to the Cancellation of Redundant Sensory Inputs

Bol¹,

Marsat²,

Harvey‐Girard³

et al. 2011

Journal of Neuroscience

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For optimal sensory processing, neural circuits must extract novel, unpredictable signals from the redundant sensory input in which they are embedded, but the detailed cellular and network mechanisms that implement such selective cancellation are presently unknown. Using a combination of modeling and experiment, we characterize in detail a cerebellar circuit in weakly electric fish, showing how it can carry out this computation. We use a model incorporating the wide range of experimentally estimated parallel fiber feedback delays and a burst-induced LTD rulederivedfrominvitroexperimentstoexplaintheprecisecancellationofredundantsignalsobservedinvivo.Ourmodeldemonstrateshowthe backpropagation-dependent burst dynamics adjusts the temporal pairing width of the plasticity mechanism to precisely match the frequency of the redundant signal. The model also makes the prediction that this cerebellar feedback pathway must be composed of frequency-tuned channels; this prediction is subsequently verified in vivo, highlighting a novel and general capability of cerebellar circuitry.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Frequency-Tuned Cerebellar Channels and Burst-Induced LTD Lead to the Cancellation of Redundant Sensory Inputs

Bol¹,

Marsat²,

Harvey‐Girard³

et al. 2011

Journal of Neuroscience

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“…The DCN processes externally-generated auditory stimuli partly by comparing them with the sounds produced by an animal’s own movements (Roberts and Portfors, 2008). A cerebellar-like circuitry, consisting of a principal output cell, the fusiform cell, and several inhibitory interneurons (Fig.…”

Section: Multisensory Integration In the Cochlear Nucleusmentioning

confidence: 99%

Listening to another sense: somatosensory integration in the auditory system

Stefanescu

Martel

et al. 2014

Cell Tissue Res

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Conventionally, sensory systems are viewed as separate entities, each with its own physiological process serving a different purpose. However, many functions require integrative inputs from multiple sensory systems, and sensory intersection and convergence occur throughout the central nervous system. The neural processes for hearing perception undergo significant modulation by the two other major sensory systems, vision and somatosensation. This synthesis occurs at every level of the ascending auditory pathway: the cochlear nucleus, inferior colliculus, medial geniculate body, and the auditory cortex. In this review, we explore the process of multisensory integration from 1) anatomical (inputs and connections), 2) physiological (cellular responses), 3) functional, and 4) pathological aspects. We focus on the convergence between auditory and somatosensory inputs in each ascending auditory station. This review highlights the intricacy of sensory processing, and offers a multisensory perspective regarding the understanding of sensory disorders.

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“…An analogous morphological arrangement in the mammalian dorsal cochlear nucleus is hypothesized to support a similarly analogous function [Montgomery et al, 1995;Roberts and Portfors, 2008].…”

Section: Primary Inputs To Ld and Ld-rfmentioning

confidence: 99%

Otolith End Organ Projections to Auditory Neurons in the Descending Octaval Nucleus of the Goldfish, <b><i>Carassius auratus</i></b>: A Confocal Analysis

McCormick

Wallace²

2012

Brain Behav Evol

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The distribution of axons from the saccule, lagena, and utricle to descending octaval nucleus neurons that project to the auditory midbrain in the goldfish is reported. We have divided these auditory projection neurons, located in the dorsal portion of the descending octaval nucleus (dDO), into two groups, medial and lateral, each of which contains several neuronal populations based on morphology and location. At most levels of the dDO, there are three medial and three lateral populations; the rostral dDO contains an additional lateral population. The saccule provides input to each of the seven medial and lateral populations but appears to be the exclusive/nearly exclusive source of primary input to the most dorsal cell group of the medial population. Along with the saccule, the lagena and utricle each supply the remaining six medial and lateral populations. Neurons in each of these populations receive input from more than one end organ. One medial and one lateral population include neurons that receive remarkably large contacts from utricular afferents. Overall, the results reveal a more substantial input from the lagena and utricle to the main first-order auditory nucleus in the goldfish than was previously recognized, suggest this nucleus is composed of functionally distinct populations, and relate to functional and evolutionary issues about hearing in early vertebrates.

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Design principles of sensory processing in cerebellum-like structures

Cited by 28 publications

References 110 publications

Frequency-Tuned Cerebellar Channels and Burst-Induced LTD Lead to the Cancellation of Redundant Sensory Inputs

Frequency-Tuned Cerebellar Channels and Burst-Induced LTD Lead to the Cancellation of Redundant Sensory Inputs

Listening to another sense: somatosensory integration in the auditory system

Otolith End Organ Projections to Auditory Neurons in the Descending Octaval Nucleus of the Goldfish, <b><i>Carassius auratus</i></b>: A Confocal Analysis

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