Design Principles of Lipid-like Ionic Liquids for Gene Delivery

Siegel, David J.; Anderson, Grace I.; Paul, Lauren M.; Seibert, Philipp J.; Hillesheim, Patrick C.; Sheng, Yinghong; Zeller, Mat­thias; Taubert, Andreas; Werner, P.; Balischewski, Christian; Michael, Scott F.; Mirjafari, Arsalan

doi:10.1021/acsabm.1c00252

Cited by 18 publications

(10 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, this is not an unusual phenomenon for ILs because upon cooling, viscous glassy liquids are formed that resist recrystallization. 41 Along with T m , viscosity, a key parameter affecting mass transfer and diffusion, is another fluid characteristic of the ILs in which lower values are favorable for CO 2 capture. Accordingly, the dynamic viscosity, kinetic viscosity, and density of the ILs were measured over the temperature at the range of 20−80 °C at 1 atm (see the SI, Figure S1 42 In light of this consideration, it seemed worthwhile to employ these ILs to serve as readily made materials with discrete structural differences for DAC.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Direct Air Capture of CO₂ via Ionic Liquids Derived from “Waste” Amino Acids

Recker

Green

Soltani

et al. 2022

ACS Sustainable Chem. Eng.

Self Cite

View full text Add to dashboard Cite

Direct capture of CO 2 from anthropogenic emissions is an imperative societal task as the concentration of global atmospheric CO 2 continues to increase drastically. The longterm goal of negative emission requires methods to remove carbon directly from the atmosphere, oceanwater, and nonpoint sources. Ionic liquids (ILs) have had a pivotal impact on finding and implementing innovative solutions that enable a more sustainable future. Here, we report the first example of an IL-enabled approach for direct CO 2 capture from the atmosphere on a laboratory scale. These de novo bioderived materials represent an ideal milieu for direct carbon capture applications because of their nonvolatility and a priori low toxicity. Easily prepared liquid salts based on a mixture of three common amino acids, valine, leucine, and isoleucine, were found to be effective sorbents for ready and reversible CO 2 sequestration from air despite its very low concentration. Collectively known as branched-chain amino acid, they are commonly derived from biowaste products, for example, feathers, fur, and even human hair. Therefore, the resultant ILs from the "waste" amino acids provide an exciting prospect in terms of CO 2 transformation and waste utilization. We provided valuable design insights for engineering structure−property relationships in amino acid-based ILs. The impact of moisture on the absorption characteristics and capacity was evaluated in ambient conditions. We postulate that the high capture efficiency and stability of these ILs make them superior to present amine-and alkali-assisted approaches for the direct air capture of CO 2 as a scalable process.

show abstract

Section: ■ Results and Discussionmentioning

confidence: 99%

“…melting point or crystallization), as evidenced by the lack of endothermic/exothermic peaks in the differential scanning calorimetry (DSC) curves, reflecting the broad liquid range associated with the ILs. In fact, this is not an unusual phenomenon for ILs because upon cooling, viscous glassy liquids are formed that resist recrystallization …”

Section: Resultsmentioning

confidence: 99%

Direct Air Capture of CO₂ via Ionic Liquids Derived from “Waste” Amino Acids

Recker

Green

Soltani

et al. 2022

ACS Sustainable Chem. Eng.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The effectiveness with which LIL‐DNA preparations can deliver DNA to HEK 293T cells in a test tube demonstrates the potential use of LIL cationic lipids in DNA delivery. [ 184 ] ILs have various advantages with regard to the delivery of local nucleic acids: first, ILs successfully transfer nucleic acids into target cells despite the limited permeability of the SC for nucleic acids. Second, ILs can preserve the secondary structure of nucleic acids.…”

Section: Ionic Liquid‐biomacromolecule Formulations For Transdermal D...mentioning

confidence: 99%

Ionic Liquids: Momentous Tools in Transdermal Delivery of Biomacromolecules

Tai

et al. 2023

Advanced Therapeutics

View full text Add to dashboard Cite

Transdermal drug delivery is a promising strategy characterized by minor fluctuations in blood concentrations, few adverse effects, convenience, and excellent patient compliance, especially for biomacromolecules. Conversely, traditional delivery methods are limited by their poor penetration abilities and complex preparation and application techniques. However, some inherent properties of biomacromolecules, such as large sizes, complex structure, and poor stability, can affect their ability to overcome skin barriers and reach deeper layers. Ionic liquids (ILs) are organic salts composed of asymmetric cations and anions in liquid form below 100 °C. ILs provide excellent protection for biomacromolecules and can facilitate their passage through the stratum corneum to cells for therapeutic effects. Therefore, they represent one of the most promising approaches to promoting transdermal penetration. Here, the barriers to effective transdermal delivery, including skin properties and the stability and biocompatibility of IL‐based biomacromolecule formulations, are highlighted and the current status of IL‐based biomacromolecule formulations are focused on, the tremendous advantages of using ILs based on current challenges in transdermal drug delivery are discussed, and light is shed on several ILs frequently used in the delivery of biomacromolecules.

show abstract

“…For example, incorporating a sulfur atom into aliphatic side chains grafted onto imidazolium cations considerably reduces the liquefaction temperatures of ILs relative to congeners bearing fully saturated side chains of equal length. 18 This effect is in part due to the change in torsion angles of the alkyl chains due to the incorporation of the sulfur moiety. Oxygen containing alkyl chains (i.e., ether moieties), were shown to influence thermal properties of ILs via repulsive OÁ Á ÁO interactions in the alkyl chains observed in their crystal structures.…”

Section: Introductionmentioning

confidence: 99%