Design, physico-chemical assessment and pharmacokinetics of a non-toxic orodispersible film for potential application in musculo-skeletal disorder

Sheikh, Fatima Akbar; Aamir, Muhammad Naeem; Haseeb, Muhammad Tahir; Bukhari, Syed Nasir Abbas; Haq, Muhammad Farid ul; Akhtar, Naveed

doi:10.1016/j.jddst.2021.102726

Cited by 8 publications

(6 citation statements)

References 49 publications

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“…HPMC, HEC, PVA and xanthan gum have been studied as film-forming excipients for a formulation containing meloxicam and tizanidine, along with croscarmellose, aspartame, PEG 400 and PVP K30. All the formulations exhibited similar dissolution profiles and increased bioavailability compared to the control [63]. Organoleptic excipients such as colouring and flavouring agents or sweeteners are added to the formulation to increase acceptability [59].…”

Section: Films (Odfs)mentioning

confidence: 99%

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Orally Dispersible Dosage Forms for Paediatric Use: Current Knowledge and Development of Nanostructure-Based Formulations

et al. 2022

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The paediatric population has always suffered from a lack of medicines tailored to their needs, especially in terms of accurate dosage, stability and acceptability. Orodispersible dosage forms have gone through a resurrection as an alternative to liquid formulations or fractioned solid formulations, although they are still subject to several inconveniences, among which the unpleasant taste and the low oral bioavailability of the API are the most significant hurdles in the way of achieving an optimal drug product. Nanostructures can address these inconveniences through their size and variety, owing to the plethora of materials that can be used in their manufacturing. Through the formation and functionalisation of nanostructures, followed by their inclusion in orodispersible dosage forms, safe, stable and acceptable medicines intended for paediatric use can be developed.

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Section: Films (Odfs)mentioning

confidence: 99%

“…For taste-masking purposes, rupatadine has been enclosed in ethylcellulose microparticles through spray-drying. The resulting particles were suspended in a polymeric solution and cast into ODFs; those having performed well in the electronic tongue assessment [63,64].…”

Section: Films (Odfs)mentioning

confidence: 99%

Orally Dispersible Dosage Forms for Paediatric Use: Current Knowledge and Development of Nanostructure-Based Formulations

et al. 2022

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“…To create a solution, the medicine is first dissolved in an appropriate liquid solvent. Subsequently, the solution is mixed into the polyol melt, such as polyethylene glycol, without eliminating the liquid solvent [45][46][47][48]. It's possible that the medicine or solvent of choice won't mix well with the melted polyethylene glycol.…”

Section: Solid Dispersion Methodmentioning

confidence: 99%

An Overview on Oral Thin Films–methodology, Characterization and Current Approach

BADEKAR,

BODKE,

TEKADE

et al. 2024

Int J Pharm Pharm Sci

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The pharmaceutical sector is looking for new ways to deliver drugs, and one such way is through thin films. It has been said that thin films offer an alternative to traditional dosage forms. They offer rapid, local, or systemic effects and are a very flexible platform. Furthermore, patients with dysphagia, elderly, paediatrics, or bedridden patients, as well as those who have difficulty accessing water, can easily utilize these systems on their own. There are several ways to administer these drug delivery systems, including transdermally, ocularly, buccally, sublingually, and orally. One of the most creative and patient-focused novel drug delivery systems is Orodispersible Thin Films (OTF). Numerous pharmaceutical companies and academic experts worldwide are currently investigating the potential of these films for delivering drugs derived from both synthetic and natural sources. The beauty of this special drug delivery method is that, as we can see from the subjects' consumption of conventional dosage forms (tablets, capsules), they don't require water to be consumed. Furthermore, these delivery methods do a great job of encouraging patient compliance in general, especially in the case of both older and pediatric patients. This review shows a detailed review of oral thin film its applications and method of preparation; mainly focus of this research is thin film introduction to researchers and last 10 y of research on thin film with drugs and polymers used in research.

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“…It consists of the main chain with repeating units of D-glucose connected by β1-4 linkage and a side chain of D-mannose and D-glucuronic acid [32] XG's main chain has a helical structure, which coils around a side chain through hydrogen bonding. Additionally, it exhibits some characteristic properties, such as stability under a wide range of temperatures and pH levels, high viscosity at low concentrations, and compatibility with metallic salts [33], XG is used in healthcare applications, for example, in connective tissue regeneration [34,35], smart wound dressing materials with controlled rheological properties and drug release rate [36], or as delivery systems for biologically active compounds [37][38][39] Polyurethanes (PUs) are versatile members of high-performance polymeric materials and have found various applications, such as foams, coatings, bers, adhesives, sealants, electronics, elastomers, actuators, and biomaterials. Currently, an abundant body of published research has been dedicated to the properties and applications of bio-based PUs as reinforcing materials for smart drug delivery carriers [40][41][42][43].…”

Section: Introductionmentioning

confidence: 99%

Design of a new polymeric matrix based on xanthan and polyurethane as support for the release of antifungal and anti-inflammatory drugs

Anghel

Dimofte

Spiridon

et al. 2022

Preprint

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The antifungal agent ketoconazole (K) and anti-inflammatory drug piroxicam (P) were incorporated into xanthan (Xn) or esterified xanthan with oleic acid (XnOA) and polyurethane (PU) matrix, targeting the development of delivery devices for the bioactive principles with possible applications as topical drug carriers. The drug encapsulation had an impact on the mechanical strength of the Xn-PU and XnOA-PU matrices. In contrast to those without bioactive compounds, which only demonstrated a compressive nominal stress of 32.18 kPa (sample Xn-PU) at 71.26% strain, the compressive strength of the biomaterials increased to roughly 50.04 kPa (sample Xn-PU-K) at 71.34% strain. The value of the compressive strength dropped to around 30.67 kPa when a second drug was entrapped inside the Xn-PU matrix (sample Xn-PU-P/K), while the maximum sustained strain increased to 87.21%. The Weibull model provided the best fit for the drug release kinetics. In contrast to the materials containing Xn-PU, those based on XnOA-PU released the active principles more slowly (the release rate constant displays low values). All materials display antimicrobial activity. Additionally, a higher amount of piroxicam is released from XnOA-PU-P (64%) than from Xn-PU-P (44%), which reveals a more pronounced anti-inflammatory activity of the former system (82.8% inhibition), compared to the latter (71% inhibition). According to the results, materials based on polyurethane and modified or unmodified xanthan could be used as topical drug carriers to release piroxicam and ketoconazole.

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Design, physico-chemical assessment and pharmacokinetics of a non-toxic orodispersible film for potential application in musculo-skeletal disorder

Cited by 8 publications

References 49 publications

Orally Dispersible Dosage Forms for Paediatric Use: Current Knowledge and Development of Nanostructure-Based Formulations

Orally Dispersible Dosage Forms for Paediatric Use: Current Knowledge and Development of Nanostructure-Based Formulations

An Overview on Oral Thin Films–methodology, Characterization and Current Approach

Design of a new polymeric matrix based on xanthan and polyurethane as support for the release of antifungal and anti-inflammatory drugs

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