Design parameters for rotating cylindrical filtration

Schwille, John A.; Mitra, Deepanjan; Lueptow, Richard M.

doi:10.1016/s0376-7388(02)00016-9

Cited by 39 publications

(12 citation statements)

References 17 publications

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“…The key advantage of rotating filtration over other types of filtration is that the Taylor vortices constantly wash particles away from the inner cylinder, preventing them from plugging the pores of the membrane. 27,28 While radial throughflow between two porous cylinders is somewhat different from rotating filtration in which the outer cylinder is nonporous, it can provide insight into the fundamental physics that alter the stability of Taylor-Couette flow when a radial throughflow is present.…”

Section: Introductionmentioning

confidence: 99%

Stability of Taylor–Couette flow in a finite-length cavity with radial throughflow

2008

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Linear stability analysis predicts that a radial throughflow in a Taylor-Couette system will alter the stability of the flow, but the underlying physics for the stabilization of the flow is unclear. We investigate the impact of radial inflow and outflow on Taylor vortex flow and wavy vortex flow in a finite-length cavity via direct numerical simulation using a three-dimensional spectral method. The numerical simulations are consistent with linear stability predictions in that radial inflow and strong radial outflow have a stabilizing effect, while weak radial outflow destabilizes the system slightly. A small radial outflow velocity enhances the strength of the Taylor vortices resulting in destabilization of the base flow, whereas strong radial outflow and radial inflow reduce vortex strength, thus stabilizing the system. The transition to wavy vortex flow is unaffected by small radial outflow, but is stabilized for radial inflow. For strong radial outflow the wavy vortex flow includes localized dislocations in the vortex structure.

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Section: Introductionmentioning

confidence: 99%

Stability of Taylor–Couette flow in a finite-length cavity with radial throughflow

2008

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“…The characteristics and chemical compositions of cassava root depend on variety, age and environmental growing conditions (Galliard and Bowler, 1987). Starch loss in the process mainly occurs due to inappropriate design and operation of the extractor (Schwille et al, 2002). The starch loss with pulp residues are approximately US$2 million annually in one factory with a capacity of 200 t a day (Saengchan et al, 2014).…”

Section: List Of Symbols Amentioning

confidence: 99%

Enhancement of starch-pulp separation in centrifugal-filtration process: Effects of particle size and variety of cassava root on free starch granule separation

Saengchan

Nopharatana

Lerdlattaporn

et al. 2015

Food and Bioproducts Processing

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“…Despite the wide use of RCF systems, the design and definition of operational conditions remain largely empirical, partly due to the complex particle dynamics and turbulent fluid flow. Efforts have been made by several researchers to fill this knowledge gap . These studies revealed key features of RCF systems, but are mainly limited to conditions of laminar to weakly turbulent conditions with low permeability filters, thus outside the design space that is relevant for RCF systems used in animal cell perfusion processes.…”

Section: Introductionmentioning

confidence: 99%

“…Efforts have been made by several researchers to fill this knowledge gap. [13][14][15][16] These studies revealed key features of RCF systems, but are mainly limited to conditions of laminar to weakly turbulent conditions with low permeability filters, thus outside the design space that is relevant for RCF systems used in animal cell perfusion processes. However, recent experimental particleimaging velocimetry (PIV) studies were carried out under conditions actually applied in industrial animal cell perfusion processes and gave evidence of interesting features, such as the persistence of Taylor-Couette vortices and the slip condition at the filter surface, despite the highly turbulent conditions and highly permeable filter elements.…”

Section: Introductionmentioning

confidence: 99%

Rotating cylindrical filters used in perfusion cultures: CFD simulations and experiments

Figueredo‐Cardero

Martínez

Chico

et al. 2014

Biotechnology Progress

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The particle and fluid dynamics in a rotating cylindrical filtration (RCF) system used for animal cell retention in perfusion processes was studied. A validated CFD model was used and the results gave numerical evidence of phenomena that had been earlier claimed, but not proven for this kind of application under turbulent and high mesh permeability conditions, such as bidirectional radial exchange flow (EF) through the filter mesh and particle (cells) lateral migration. Taylor vortices were shown to cause EF 10-100 times higher than perfusion flow, indicating that EF is the main drag source, at least in early stages of RCF operation. Particle lateral migration caused a cell concentration reduction (CCR) near the filter surface of approximately 10%, contributing significantly to cell separation in RCF systems and giving evidence that the mesh sieving effect is not the sole phenomenon underlying cell retention in RCF systems. Filter rotation rate was shown to significantly affect both EF and CCR. A higher separation efficiency (measured experimentally at 2,000-L bioreactor scale) and an enhanced CCR (predicted by the numerical simulations) were found for the same rotation rate range, indicating that there is an optimal operational space with practical consequences on RCF performance. Experimental data of a large-scale perfusion run employing the simulated RCF showed high cell viabilities for over 100 days, which is probably related to the fact that the computed shear stress level in the system was shown to be relatively low (below 20 Pa under all tested conditions).

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Design parameters for rotating cylindrical filtration

Cited by 39 publications

References 17 publications

Stability of Taylor–Couette flow in a finite-length cavity with radial throughflow

Stability of Taylor–Couette flow in a finite-length cavity with radial throughflow

Enhancement of starch-pulp separation in centrifugal-filtration process: Effects of particle size and variety of cassava root on free starch granule separation

Rotating cylindrical filters used in perfusion cultures: CFD simulations and experiments

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