Design paper: The DEMO trial: A randomized, parallel-group, observer-blinded clinical trial of aerobic versus non-aerobic versus relaxation training for patients with light to moderate depression

Krogh, Jesper; Petersen, L.; Timmermann, Michael; Saltin, Bengt; Nordentoft, Merete

doi:10.1016/j.cct.2006.07.001

Cited by 14 publications

(4 citation statements)

References 64 publications

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“…The prevalence of depressive symptoms in this sample was four times that found in the general population, 40 and is similar to the 20–25% depression prevalence reported in patients undergoing coronary bypass surgery 41 and the 20% depression prevalence associated with chronic disease. 40 These findings underscore that depressive symptoms are relatively common in overweight, working adults yet are often undetected and untreated.…”

Section: Discussionsupporting

confidence: 84%

Psychological Factors Are Important Correlates of Dietary Pattern in Overweight Adults

Grossniklaus

Dunbar²,

Tohill³

et al. 2010

Journal of Cardiovascular Nursing

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Introduction and Purpose Abdominal obesity, the central distribution of adipose tissue, is a well established cardiometabolic disease risk factor. The prevalence has steadily increased since 1988, and now more than 50% of adults have abdominal obesity. Psychological distress coupled with increased dietary energy density (ED) may contribute to abdominal obesity. Guided by the stress and coping model, this study examined the relationship between psychological factors (perceived stress and depressive symptoms) and dietary ED in overweight, working adults. The first hypothesis tested if psychological factors explained a significant amount of food and beverage ED variance above that accounted for by demographic factors. The second hypothesis tested if psychological factors explained a significant amount of food and non-alcoholic beverage ED variance above that accounted for by demographic factors. Post hoc analyses compared macronutrient composition and food group pattern between overweight, working adults with and without depressive symptoms. Methods This descriptive, cross sectional, correlation study was comprised of 87 overweight, working adults; mean age, 41.3 (SD 10.2) years; mean body mass index (BMI), 32.1 (SD 6.1) kg/m2; 73.6% women; 50.6% African-American. Participants completed the Beck Depression Inventory-II (BDI-II) and Perceived Stress Scale (PSS); weighed three day food record analyzed for caloric intake (kilocalories) and weight (grams) of consumed foods and beverages which were used to calculate ED (kilocalories/gram). Height and weight were measured to calculate BMI. Descriptive statistics, Mann-Whitney U and sequential regression modeling were used for data analysis. Results Depressive symptoms were reported by 21.9% of participants, and explained variance in food and beverage ED above that accounted for by African-American race and reporting adequate caloric intake. Depressive symptoms explained variance in food and non-alcoholic beverage ED above that accounted for male gender, African-American race and reporting adequate caloric intake. Perceived stress and depressive symptoms were positively correlated; however, perceived stress was not a significant predictor of food and beverage ED. Conclusion Depressive symptoms, potentially modifiable, were four times that found in the general population, and independently predicted increased food and beverage ED. Further research is needed to determine if improvements in depressive symptoms alter dietary ED, potentially reducing cardiometabolic disease risk.

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Section: Discussionsupporting

confidence: 84%

Psychological Factors Are Important Correlates of Dietary Pattern in Overweight Adults

Grossniklaus

Dunbar²,

Tohill³

et al. 2010

Journal of Cardiovascular Nursing

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“…The GenPod/NEWMEDS and Harvard i2b2 studies, which appeared in the replication of the primary analysis of this dataset, did not have AAO data available and were not included. Four new replication studies were available: 1) a collection of samples available through the University of Mu¨nster (38, 39); 2) a combination of RADIANT cases from Denmark (40), the Danish DEMO and PRISME studies of MDD (41, 42), and a set of Danish population control subjects; 3) the CONVERGE (China Oxford and VCU Experimental Research on Genetic Epidemiology) study of MDD cases and control subjects recruited in China (18, 43, 44); and 4) the Generation Scotland study, which included measures on MDD (45). These are outlined, alongside the definitions of AAO, in Supplemental Methods.…”

Section: Methodsmentioning

confidence: 99%

Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium

Power

Tansey

Buttenschøn

et al. 2017

Biological Psychiatry

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173

140

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BackgroundMajor depressive disorder (MDD) is a disabling mood disorder, and despite a known heritable component, a large meta-analysis of genome-wide association studies revealed no replicable genetic risk variants. Given prior evidence of heterogeneity by age at onset in MDD, we tested whether genome-wide significant risk variants for MDD could be identified in cases subdivided by age at onset.MethodsDiscovery case-control genome-wide association studies were performed where cases were stratified using increasing/decreasing age-at-onset cutoffs; significant single nucleotide polymorphisms were tested in nine independent replication samples, giving a total sample of 22,158 cases and 133,749 control subjects for subsetting. Polygenic score analysis was used to examine whether differences in shared genetic risk exists between earlier and adult-onset MDD with commonly comorbid disorders of schizophrenia, bipolar disorder, Alzheimer’s disease, and coronary artery disease.ResultsWe identified one replicated genome-wide significant locus associated with adult-onset (>27 years) MDD (rs7647854, odds ratio: 1.16, 95% confidence interval: 1.11–1.21, p = 5.2 × 10-11). Using polygenic score analyses, we show that earlier-onset MDD is genetically more similar to schizophrenia and bipolar disorder than adult-onset MDD.ConclusionsWe demonstrate that using additional phenotype data previously collected by genetic studies to tackle phenotypic heterogeneity in MDD can successfully lead to the discovery of genetic risk factor despite reduced sample size. Furthermore, our results suggest that the genetic susceptibility to MDD differs between adult- and earlier-onset MDD, with earlier-onset cases having a greater genetic overlap with schizophrenia and bipolar disorder.

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“…The Denmark 3 cohort includes individuals from the Danish contribution to the Depression Network Study project and is described in detail by Farmer et al (2004) and Breen et al (2011). The Denmark 4 cohort includes individuals from the Danish DEMO trial, described in detail by Krogh et al (2007). All cases fulfilled the ICD-10 diagnostic criteria for depression.…”

Section: Participants For the Case-control Studymentioning

confidence: 99%

An association study between the norepinephrine transporter gene and depression

Buttenschøn

Jacobsen²,

Grynderup

et al. 2013

Psychiatric Genetics

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A potential approach for identification of candidate genes for depression is characterization of chromosomal rearrangements. Through analysis of a chromosome translocation in an individual with recurrent depression, we identified a potential candidate gene: the norepinephrine transporter (NET; SLC6A2 for solute carrier 6 family member 2). The gene is responsible for the reuptake of norepinephrine and dopamine into presynaptic nerve terminals and the norepinephrine system appears to play an important role in depression. We therefore analyzed genetic variants within SLC6A2 for association with depression in 408 affected and 559 control individuals from Denmark. After quality control of the genotypes, 31 of 45 single nucleotide polymorphisms (SNPs) were left for analyses. One SNP showed a nominal association with depression but did not survive correction for multiple testing. The results from our study do not suggest SLC6A2 as a susceptibility gene for depression in the Danish population.

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Design paper: The DEMO trial: A randomized, parallel-group, observer-blinded clinical trial of aerobic versus non-aerobic versus relaxation training for patients with light to moderate depression

Cited by 14 publications

References 64 publications

Psychological Factors Are Important Correlates of Dietary Pattern in Overweight Adults

Psychological Factors Are Important Correlates of Dietary Pattern in Overweight Adults

Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium

An association study between the norepinephrine transporter gene and depression

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