Design optimization of L-C filters

Loree, D.L.; O'Loughlin, J.P.

doi:10.1109/modsym.2000.896184

Cited by 9 publications

(2 citation statements)

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“…The mode of action of antibiotics is also concentration-dependent. Commonly used bactericidal antibiotics are fluoroquinolones and β-lactam, whereas bacteriostatic antibiotics are chloramphenicol, tetracyclines, trimethoprim/sulfamethoxazole, linezolid, macrolides, and clindamycin. , Despite their extensive antimicrobial activity, bacteriostatic antibiotics often inhibit the growth of microbes, thus they work synergistically with the host’s immune system to get rid of the microbes. ,− Treating the patient with this class of antibiotics does not require intensive monitoring. , In our study, we have used different antibiotics, among which norfloxacin and ciprofloxacin are bactericidal (BC) in nature, while chloramphenicol and tetracycline are bacteriostatic (BS). , These antibiotics are used for the treatment of many infectious diseases; for example, norfloxacin is used to treat acute diarrhea, complicated urinary tract infections (UTIs), and gonococcal urethritis; ciprofloxacin is effective in treating UTIs, gall bladder infections, serious gastrointestinal infections, eye infections, gonorrhea; chloramphenicol is effective as conjunctivitis eyedrops, ointment for surgical wounds; tetracycline is used for the treatment of many bacterial infections including acne vulgaris. − This broad binary classification system of antibiotics varies in different organisms with corresponding concentrations . In our study, we have used Escherichia coli to evaluate the efficacy of these antibiotics.…”

Section: Introductionmentioning

confidence: 99%

Sensing the Bactericidal and Bacteriostatic Antimicrobial Mode of Action Using Raman Deuterium Stable Isotope Probing (DSIP) in Escherichia coli

Karlo,

Vijay,

Phaneeswar

et al. 2024

ACS Omega

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The mode of action of antibiotics can be broadly classified as bacteriostatic and bactericidal. The bacteriostatic mode leads to the arrested growth of the cells, while the bacteriocidal mode causes cell death. In this work, we report the applicability of deuterium stable isotope probing (DSIP) in combination with Raman spectroscopy (Raman DSIP) for discriminating the mode of action of antibiotics at the community level. Escherichia coli, a well-known model microbe, was used as an organism for the study. We optimized the concentration of deuterium oxide required for metabolic activity monitoring without compromising the microbial growth. Our findings suggest that changes in the intensity of the C–D band in the high-wavenumber region could serve as a quantifiable marker for determining the antibiotic mode of action. This can be used for early identification of the antibiotic’s mode of action. Our results explore the new perspective that supports the utility of deuterium-based vibrational tags in the field of clinical spectroscopy. Understanding the antibiotic’s mode of action on bacterial cells in a short and objective manner can significantly enhance the clinical management abilities of infectious diseases and may also help in personalized antimicrobial therapy.

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Section: Introductionmentioning

confidence: 99%

Sensing the Bactericidal and Bacteriostatic Antimicrobial Mode of Action Using Raman Deuterium Stable Isotope Probing (DSIP) in Escherichia coli

Karlo,

Vijay,

Phaneeswar

et al. 2024

ACS Omega

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“…Cost considerations for single components can be found in [4], [5], [6] for semiconductors, inductive components or heatsinks. The costs are indirectly estimated by considering representative physical quantities such as the total chip area or the stored energy and volume of the passive components.…”

Section: Introductionmentioning

confidence: 99%

Component cost models for multi-objective optimizations of switched-mode power converters

Burkart

Kolar

2013

2013 IEEE Energy Conversion Congress and Exposition

105

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Besides product differentiation, cost is a key parameter for market success and sustainable competitive advantage of industrial companies. Academic research in the field of power electronics, however, is often confined to the search for technical innovations or optimizations with focus on pure physical performance indices while the cost dimension is neglected. An explanation for the lack of such cost considerations is the generally poor availability of cost data in academia. This paper discusses the necessity of an increased awareness and sensitivity towards costs and the related opportunities for academic research. Furthermore, cost models for the power semiconductors, the passive components, the cooling systems and the printed circuit boards of switched-mode power converters with an approximate rated power between 5 and 50 kW are derived. Based on manufacturer prices for large ordering quantities, numerical values for the cost model parameters are proposed. An example of a multiobjective comparison of different power converter topologies for photovoltaic applications regarding efficiency, volume and total semiconductor chip area is extended by the cost dimension to demonstrate the benefits of employing the developed cost models.

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A new active output filter (AOF) for variable speed constant frequency (VSCF) power system in aerospace applications

Alhuwaishel

Morsy

Enjeti

2015

2015 IEEE Energy Conversion Congress and Exposition (ECCE)

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Design optimization of L-C filters

Cited by 9 publications

References 0 publications

Sensing the Bactericidal and Bacteriostatic Antimicrobial Mode of Action Using Raman Deuterium Stable Isotope Probing (DSIP) in Escherichia coli

Sensing the Bactericidal and Bacteriostatic Antimicrobial Mode of Action Using Raman Deuterium Stable Isotope Probing (DSIP) in Escherichia coli

Component cost models for multi-objective optimizations of switched-mode power converters

A new active output filter (AOF) for variable speed constant frequency (VSCF) power system in aerospace applications

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