Design, optimization and in-vitro study of folic acid conjugated-chitosan functionalized PLGA nanoparticle for delivery of bicalutamide in prostate cancer

Dhas, Namdev; Ige, Pradum Pundlikrao; Kudarha, Ritu

doi:10.1016/j.powtec.2015.04.053

Cited by 95 publications

(46 citation statements)

References 40 publications

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“…(3) Preparation of PLGA NPs Coated with FA/CS Chemical Conjugate (FA/CS Chemical NPs) (for Comparison Purpose). FA/CS conjugated polymer was synthesized based on a carbodiimide reaction [28,31,32]. FA, 1,3-dicyclohexylcarbodiimide (DCC), and N-hydroxysuccinimide (NHS) (molar ratio of FA DCC NHS = 1 1 2 1 2) were stirred in 20 mL DMSO for 12 h. The NHS-FA was obtained by crystallization into an ice-cold anhydrous ether solution containing 30% acetone.…”

Section: Adsorption Of Cs and Fa Onto Plga Npsmentioning

confidence: 99%

Physical Absorption of Folic Acid and Chitosan on Dihydroartemisinin-Loaded Poly-Lactic-Co-Glycolic Acid Nanoparticles via Electrostatic Interaction for Their Enhanced Uptake and Anticancer Effect

Nguyen

Tran

Thi

et al. 2019

Journal of Nanomaterials

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In this study, dihydroartemisinin (DAR), an anticancer agent with low toxicity, was loaded into poly-lactic-co-glycolic acid (PLGA) nanoparticles. The obtained PLGA cores were then coated with chitosan (CS) and/or folic acid (FA) by electrostatic interactions to enhance their anticancer and cellular uptake properties. DAR-loaded PLGA nanoparticles were prepared by the solvent evaporation method. CS and FA solutions at different ratios were dispersed concurrently into the PLGA suspension to facilitate electrostatic interactions and form nanosuspensions. The physiochemical properties of nanoparticles such as average particle size (Z), polydispersity index (PDI), zeta potential (ZP), TEM image, X-ray diffraction, and encapsulation efficiency were determined. We then determined the role of FA and CS coating on the nanoparticle surface in cytotoxicity, cellular uptake, and apoptosis. We show that the resultant nanoparticles were spherical and uniform, with a coating layer containing FA and CS covering PLGA cores with a Z of 223.5±4.28 nm, PDI of 0.209±0.03, and ZP of 15.75±1.3 mV. Both FA and CS improved the cytotoxicity of nanoparticles compared to free DAR and PLGA nanoparticles in HL-60 and KB cancer cell lines. Further, FA enhanced the cellular uptake of nanoparticles to a greater extent than CS. However, CS contributed more to apoptosis induction than FA.

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Section: Adsorption Of Cs and Fa Onto Plga Npsmentioning

confidence: 99%

Physical Absorption of Folic Acid and Chitosan on Dihydroartemisinin-Loaded Poly-Lactic-Co-Glycolic Acid Nanoparticles via Electrostatic Interaction for Their Enhanced Uptake and Anticancer Effect

Nguyen

Tran

Thi

et al. 2019

Journal of Nanomaterials

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“…53 In a colloidal dispersion, the magnitude of the ZP indicates the degree of electrostatic repulsion between similarly charged particles. In general, a nanoformulation is considered stable if it has a high potential (>+30 mV or <À30 mV); 54,55 however, for particles intended to be in systemic circulation, a near-neutral ZP is preferred to avoid interactions with in vivo plasma components. Furthermore, a positive potential causes toxicity due to the excessive binding affinity of the particles for cellular components.…”

Section: Evaluation Of Zeta Potentialmentioning

confidence: 99%

A chemotherapeutic approach targeting the acidic tumor microenvironment: combination of a proton pump inhibitor and paclitaxel for statistically optimized nanotherapeutics

et al. 2019

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“…In this section, the design, morphology examination as well as application of two classes of PNPs are reviewed in detail: conducting polymers including polypyrrole, polyaniline (PANi), polyacetylene, poly(p-phenylene-vinylene) and polythiophene which have been a popular subject of exploration [42] and biosafe PNPs that are another important class of polymers and have many advantages such as biocompatibility and biodegradability. They are easily removed from the body by the normal metabolic path or they can have susceptibility to fungal enzymatic degradation [43][44][45].…”

Section: Application Of Pnpsmentioning

confidence: 99%

“…In addition, it was mentioned that the obtained scaffolds containing PLGA NPs could be used as bioactive bone tissue engineering scaffolds with the potential of localized delivery of biological molecules (Figure 8). Folic acid (FA)-conjugated chitosan (CS)-functionalized PLGA nanocarriers for treatment of prostate cancer were designed by Dhas et al [43]. PLGA NPs were coated using FA-CS conjugates for binding with folate receptors.…”

Section: Application Of Biodegradable Nanostructure Polymersmentioning

confidence: 99%

Polymeric nanoparticles: Recent development in synthesis and application

Mallakpour¹,

Behranvand²

2016

Express Polym. Lett.

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Abstract. Nanosized particles have attractive characteristics, which have received considerable attention in the last decade. Polymeric nanoparticles (PNP)s are solid particles or particulate dispersions with size in the range of 10-1000 nm. Due to the very small size, the surface area is very large so the percentage of atoms or molecules on the surface is significantly increased, which is expected to have extensive applications in various fields such as drug delivery systems, biosensors, catalysts, nanocomposites, agriculture and environment. The aim of the present paper is to critically review enhancement in the field of synthesis and different application of novel PNPs in various area from drug delivery to composite fabrication. Literature sources were mainly taken from the publications of 2011 and later; though, for a basic depiction of the structural principles, older publications have also been cited. Vol.10, No.11 (2016) 895-913 Available online at www.expresspolymlett.com DOI: 10.3144/expresspolymlett.2016.84 * Corresponding author, e-mail: mallak@cc.iut.ac.ir © BME-PT of these methods as low cost and safe ways should be highlighted. Furthermore, their importance according to their applications discusses. We will also show some properties of them such as morphology and biological activity. Keywords: biopolymers, biocomposites, polymeric nanoparticles, drug delivery systems, biosensors eXPRESS Polymer Letters

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Design, optimization and in-vitro study of folic acid conjugated-chitosan functionalized PLGA nanoparticle for delivery of bicalutamide in prostate cancer

Cited by 95 publications

References 40 publications

Physical Absorption of Folic Acid and Chitosan on Dihydroartemisinin-Loaded Poly-Lactic-Co-Glycolic Acid Nanoparticles via Electrostatic Interaction for Their Enhanced Uptake and Anticancer Effect

Physical Absorption of Folic Acid and Chitosan on Dihydroartemisinin-Loaded Poly-Lactic-Co-Glycolic Acid Nanoparticles via Electrostatic Interaction for Their Enhanced Uptake and Anticancer Effect

A chemotherapeutic approach targeting the acidic tumor microenvironment: combination of a proton pump inhibitor and paclitaxel for statistically optimized nanotherapeutics

Polymeric nanoparticles: Recent development in synthesis and application

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