Design, Optimization and Evaluation of Ibuprofen Fast Dissolving Tablets Employing Starch Phthalate-a Novel Superdisintegrant

Kumar, R. Santosh; Kumari, Annu; Latha, B. Kusuma; Mallika, T.

doi:10.22159/ijcpr.2019v11i5.35702

Cited by 3 publications

(9 citation statements)

References 3 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, a powder mixture was applied with talc and magnesium stearate. Mixed blend was eventually compressed using eight-station rotator Press Shakti Machineries Pvt, Ltd., Ahmedabad, India) [6,7].…”

Section: Rada Et Almentioning

confidence: 99%

“…It is usually measured using the Monsanto hardness tester, which allows the force, with the aid of its built-in spring, to fall diametrically on the tablet. It is expressed in terms of kg/cm 2 [7].…”

Section: Hardnessmentioning

confidence: 99%

“…In the petri dish, the tissue paper was put in and about 10 ml of amaranth solution was poured into it so that the tissue paper would absorb the color solution. The tablets were then placed individually on the surface of the tissue paper, surface and the time taken by the tablet to absorb the color was noted [7].…”

Section: Wetting Timementioning

confidence: 99%

“…The same wetting time method was followed to find out the water absorption ratio, but the tablet should be re-weighted after the tablet absorbs the color water and should be measured using the following formula [7].…”

Section: Water Absorption Ratiomentioning

confidence: 99%

“…disintegration media, maintained at a temperature range of 37±0.2°C. The time taken by the tablet for complete disintegration with no solid, palatable mass in the apparatus was recorded [7].…”

Section: Rada Et Almentioning

confidence: 99%

See 4 more Smart Citations

Design, Optimization, and Evaluation of Ibuprofen Fast-Dissolving Tablets Employing Starch Valerate – A Novel Super Disintegrant

Rada¹,

Ramya²,

Kandukuri³

2021

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The main aim is to design, optimize, and evaluate ibuprofen fast-dissolving tablets by employing starch valerate-A novel super disintegrant. Methods: The fast-dissolving tablet of ibuprofen was prepared by employing starch valerate as super disintegrant in different proportions in each case by direct compression method using 23 factorial design, sodium starch glycolate, and crospovidone used as super disintegrants. In the 23 factorial design, these super disintegrants were applied to investigate the interaction effects of three variables, that is, (a) starch valerate, (b) sodium starch glycolate, and (c) crospovidone. The drug content, hardness, friability, disintegration time, and other dissolution characteristics were determined. Results: The starch valerate prepared was found to be fine, free-flowing, slightly crystalline powder. Starch xanthate exhibited good swelling in water with 125.2%. All the fast-dissolving tablets formulated employing starch valerate were of good quality with regard to drug content (100±5%), hardness (3.6–3.8 kg/sq. cm), and friability (0.11-0.12%). The disintegration time of all the formulated tablets was found to be in the range of 12±0.02 to 30±0.02s. The optimized formulation FL8 has the least disintegration time, that is, 12±0. 02s. The in vitro wetting time of the formulated tablets was found to be in the range of 21±0.09 to 44±0.10s. The in-vitro wetting time was less (i.e., 90s) in optimized formulation FL8. The water absorption ratio of the formulated tablets was found to be in the range of 30±0.12 to 100±0.09%. Conclusion: Starch valerate was found to be a super disintegrant which enhanced the dissolution efficiency when combined with sodium starch glycolate, crospovidone, with the ibuprofen.

show abstract

Section: Rada Et Almentioning

confidence: 99%

Section: Hardnessmentioning

confidence: 99%

Section: Wetting Timementioning

confidence: 99%

Section: Water Absorption Ratiomentioning

confidence: 99%

Section: Rada Et Almentioning

confidence: 99%

See 3 more Smart Citations

Design, Optimization, and Evaluation of Ibuprofen Fast-Dissolving Tablets Employing Starch Valerate – A Novel Super Disintegrant

Rada¹,

Ramya²,

Kandukuri³

2021

Asian J Pharm Clin Res

View full text Add to dashboard Cite

show abstract

Novel Rp-HPLC Method Development and Validation for the Simultaneous Estimation of Saxagliptin and Glimepiride

Upadhyay

Rathore

Sapra³

et al. 2018

Int J App Pharm

View full text Add to dashboard Cite

Objective: The objective of the present study was to develop, and validate a novel reverse phase high performance liquid chromatographic (RP-HPLC) method, for simultaneous determination of saxagliptin (SAXA) and glimepiride (GLIM), in bulk mixtures, and in tablets.Methods: Determination of the drugs, SAXA and GLIM, was carried out employing ODS C18 column (250 mm X 4.6 mm i. d, 5 Âµm particle size), with diode array detector at Î»max of 230 nm. The mobile phase employed for the current study, composed of two solvents, i.e., A (acetonitrile), and B (0.1 % w/v sodium di-hydrogen orthophosphate buffer, pH 3.8 adjusted with orthophosphoric acid). The mobile phase was pumped at a flow rate of 0.75 ml/min in the gradient mode. The validation study with respect to specificity, linearity, precision, accuracy, robustness, limit of detection (LOD), and limit of quantification (LOQ), was carried out employing the ICH Guidelines.Results: The developed method was selective and linear for both the drugs, i.e., between 15.63 Âµg/ml and 250.00 Âµg/ml for SAXA, and 7.81 Âµg/ml and 125.00 Âµg/ml for GLIM, with a correlation coefficient (R2) 0.9977 and 0.9982, for SAXA, and GLIM, respectively. The % recovery obtained was 102.98Â±0.14% for SAXA, and 101.84Â±1.96% for GLIM. The LOD and LOQ values for SAXA were obtained to be 1.30 Âµg/ml, and 3.94 Âµg/ml, respectively, while for GLIM, LOD was 0.82 Âµg/ml and LOQ was 2.48 Âµg/ml. The method also exhibits good robustness for different chromatographic conditions like wavelength, flow rate, mobile phase and injection volume.Conclusion: The method was successfully employed, for the quantification of SAXA and GLIM, in the quality control of in-house developed tablets, and can be applied for the industrial use.

show abstract

Formulation and Evaluation of Gastro Retentive Floating Tablet of Amlodipine Besylate Using Natural Organic Polymers

et al. 2022

View full text Add to dashboard Cite

Objective: This study was designed to formulate and evaluate the gastro retentive floating tablets of Amlodipine besylate by using different proportions of four polymers, namely xanthan gum, gum acacia, carbopol 940, and HPMC K 100 M. Methods: Nine different batches of the floating tablets were formulated by direct compression technique. The constant amount of gas generating agents, namely, sodium bicarbonate and citric acid, were used for the floating character. The powder blend was subjected to pre-compression parameters analysis and the prepared tablets were evaluated for post-compression parameters such as hardness, friability, drug content, weight variation, floating lag time, total floating time, and swelling index. In vitro dissolution study was carried out for 12 h as per the specification of Indian Pharmacopeia 2018. Results: For the optimized batch (4th batch), all the physicochemical parameters like angle of repose (33.47), Carr’s index (17.46%), Hausner’s ratio (1.21), weight variation (221 mg), hardness (5.2 Kg/cm2), friability (0.1%), thickness (3.92 mm), dissolution (94.65% at 12 h), and drug content (92.5%) were within the acceptable limit. Furthermore, swelling index, floating lag time, and total floating time was reported to be 203.0%, 7.5 seconds,>12 h, respectively. Fourier Transform Infrared Spectroscopy analysis suggested that there is no drug excipients interaction. Conclusion: Hence, this study suggested that gastro retentive floating tablets of Amlodipine besylate can be formulated to enhance gastric residence time and thereby improve its drug release characteristics.

show abstract

Design, Optimization and Evaluation of Ibuprofen Fast Dissolving Tablets Employing Starch Phthalate-a Novel Superdisintegrant

Cited by 3 publications

References 3 publications

Design, Optimization, and Evaluation of Ibuprofen Fast-Dissolving Tablets Employing Starch Valerate – A Novel Super Disintegrant

Design, Optimization, and Evaluation of Ibuprofen Fast-Dissolving Tablets Employing Starch Valerate – A Novel Super Disintegrant

Novel Rp-HPLC Method Development and Validation for the Simultaneous Estimation of Saxagliptin and Glimepiride

Formulation and Evaluation of Gastro Retentive Floating Tablet of Amlodipine Besylate Using Natural Organic Polymers

Contact Info

Product

Resources

About