Design, optimization and characterization of a novel antibacterial chitosan-based hydrogel dressing for promoting blood coagulation and full-thickness wound healing: A biochemical and biophysical study

Mirhaji, Samaneh Sadat; Soleimanpour, Marjan; Derakhshankhah, Hossein; Jafari, Samira; Mamashli, Fatemeh; Rooki, Meisam; Karimi, Mohammad Reza; Nedaei, Hadi; Pirhaghi, Mitra; Motasadizadeh, Hamidreza; Ghasemi, Ali; Nezamtaheri, Maryam Sadat; Saadatpour, Fatemeh; Goliaei, Bahram; Delattre, Cédric; Saboury, Ali Akbar

doi:10.1016/j.ijbiomac.2023.124529

Cited by 10 publications

(2 citation statements)

References 93 publications

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“…Studies so far have focused both on developing the adequate composition of the hydrogel matrix as well as selecting additives showing beneficial properties in terms of vascular regeneration and cell proliferation [13,14]. Substances of natural [15][16][17] or synthetic [18,19] origin and their combinations [20,21] have been proposed as components of hydrogel matrixes. The investigated modifiers include antibiotics [22], herbal extracts [23], essential oils [24], and vitamins [25].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Potential of Royal-Jelly-Incorporated Hydrogel Dressings as Innovative Wound Care Materials

Kudłacik-Kramarczyk,

Krzan,

Jamroży

et al. 2023

IJMS

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The development of multifunctional dressing materials with beneficial properties for wound healing has become a recent focus of research. Many studies are being conducted to incorporate active substances into dressings to positively impact wound healing processes. Researchers have investigated various natural additives, including plant extracts and apiproducts such as royal jelly, to enhance the properties of dressings. In this study, polyvinylpyrrolidone (PVP)-based hydrogel dressings modified with royal jelly were developed and analyzed for their sorption ability, wettability, surface morphology, degradation, and mechanical properties. The results showed that the royal jelly and crosslinking agent content had an impact on the physicochemical properties of the hydrogels and their potential for use as innovative dressing materials. This study investigated the swelling behavior, surface morphology, and mechanical properties of hydrogel materials containing royal jelly. The majority of the tested materials showed a gradual increase in swelling ratio with time. The pH of the incubated fluids varied depending on the type of fluid used, with distilled water having the greatest decrease in pH due to the release of organic acids from the royal jelly. The hydrogel samples had a relatively homogeneous surface, and no dependence between composition and surface morphology was observed. Natural additives like royal jelly can modify the mechanical properties of hydrogels, increasing their elongation percentage while decreasing their tensile strength. These findings suggest possible future applications in various fields requiring high flexibility and elasticity.

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Section: Introductionmentioning

confidence: 99%

Exploring the Potential of Royal-Jelly-Incorporated Hydrogel Dressings as Innovative Wound Care Materials

Kudłacik-Kramarczyk,

Krzan,

Jamroży

et al. 2023

IJMS

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“…Meanwhile, the oligosaccharides exhibit su cient anti-infection and anti-in ammation effect, rendering the oligosaccharides more feasible for tissue repair [35,36]. Given that chitosan has obvious advantages in skin wound recovery [37], it is assumed that COS may contribute to diabetic wound healing by facilitating cell behaviors of broblast. In the present study, we examined the effects of COS on the diabetic wound healing of mice, and revealed the promoting function of COS-mediated broblasts on the wound repair.…”

Section: Introductionmentioning

confidence: 99%

Chitooligosaccharides promote healing of diabetic wounds through mediating proliferation and migration of fibroblasts

Li,

Zhang,

Wang

et al. 2024

Preprint

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Diabetic wound is difficult for healing due to disrupted cell repairing function and reduced angiogenesis, along with susceptibility to infection. Fibroblasts are crucial for wound healing by producing extracellular matrix (ECM) components and several growth factors, which are inhibited in the subjects of diabetic wounds. Chitooligosaccharides (COS), the intermediate products of chitosan degradation, are found efficient in promoting tissue repair, but less is known about their roles on diabetic wound healing. By treatment of mice diabetic wounds model, COS showed robust bioactivity in accelerating wound healing through promoting proliferation and migration of fibroblasts. COS also increased deposition of collagen III and angiogenesis at wound sites. Meanwhile, the oligosaccharides attenuated inflammatory activation by control of leukocyte infiltration and bacterial infection. Mechanistically, COS mediated cell events of fibroblasts through regulation of PI3K/Akt signaling pathway. The results have provided new bioactive material for chronic wound healing.

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Advancements in fruit preservation technologies: Harnessing chitosan, aloe vera gel, and plant-based essential oils for coating applications

Felicia,

Rovina,

Mamat

et al. 2024

Applied Food Research

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Design, optimization and characterization of a novel antibacterial chitosan-based hydrogel dressing for promoting blood coagulation and full-thickness wound healing: A biochemical and biophysical study

Cited by 10 publications

References 93 publications

Exploring the Potential of Royal-Jelly-Incorporated Hydrogel Dressings as Innovative Wound Care Materials

Exploring the Potential of Royal-Jelly-Incorporated Hydrogel Dressings as Innovative Wound Care Materials

Chitooligosaccharides promote healing of diabetic wounds through mediating proliferation and migration of fibroblasts

Advancements in fruit preservation technologies: Harnessing chitosan, aloe vera gel, and plant-based essential oils for coating applications

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