Design of vonoprazan pyrazole derivatives as potential reversible inhibitors of gastric proton pump: An in silico molecular docking study
Marko Karović,
Boško Nikolić,
Nikola Nedeljković
et al.
Abstract:Introduction/Aim. Despite the fact that proton pump inhibitors are widely used for the inhibition of gastric acid secretion, recent studies have revealed certain long-term side effects. Due to acidic environment in the stomach, it is challenging to design new competitive inhibitors of gastric proton pump with more potent inhibition of gastric acid secretion to conventional drugs. The aim of this in silico study was to assess the potential of designed vonoprazan derivatives to inhibit the gastric proton pump us… Show more
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