Design of Vaterite Nanoparticles for Controlled Delivery of Active Immunotherapeutic Proteins
Levi Collin Nelemans,
Ghizlane Choukrani,
Natasha Ustyanovska‐Avtenyuk
et al.
Abstract:Despite clinical advances in immunotherapy, still many therapeutics cause dose‐limiting (auto)immune‐mediated toxicities. Nanoparticle‐based drug delivery systems (DDS) can improve cancer immunotherapy through site‐specific delivery and controlled release of immunotherapeutics in the tumor microenvironment (TME). However, DDS face several challenges, including unspecific release. To address this, vaterite nanoparticles (VNPs) that selectively release immunotherapeutic proteins at low pH conditions find in the … Show more
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