Design of ultraviolet wavelength and standard solution concentrations in relative response factors for simultaneous determination of multi-components with single reference standard in herbal medicines

Yang, Ting-Wen; Zhao, Chao; Fan, Yong; Qi, Lian‐Wen; Li, Ping

doi:10.1016/j.jpba.2015.05.028

Cited by 13 publications

(4 citation statements)

References 10 publications

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“…For these three cases, the pharmacopoeial markers were detected but were less abundant based on ELSD detection or not specific. Additionally, in line with recently developed single standard to determine multicomponents methods (SSDMC) for the QC of single TCM herb (Gao et al, 2009), our workflow highlighted wogonoside (SC2) as a second marker for Scutellaria baicalensis (Wang et al, 2017), and E-piceid (PO1) for Polygonum cuspidatum (Yang et al, 2015).…”

Section: Marker Selectionsupporting

confidence: 53%

A Mass Spectrometry Based Metabolite Profiling Workflow for Selecting Abundant Specific Markers and Their Structurally Related Multi-Component Signatures in Traditional Chinese Medicine Multi‐Herb Formulae

et al. 2020

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In Traditional Chinese Medicine (TCM), herbal preparations often consist of a mixture of herbs. Their quality control is challenging because every single herb contains hundreds of components (secondary metabolites). A typical 10 herb TCM formula was selected to develop an innovative strategy for its comprehensive chemical characterization and to study the specific contribution of each herb to the formula in an exploratory manner. Metabolite profiling of the TCM formula and the extract of each single herb were acquired with liquid chromatography coupled to high-resolution mass spectrometry for qualitative analyses, and to evaporative light scattering detection (ELSD) for semi-quantitative evaluation. The acquired data were organized as a feature-based molecular network (FBMN) which provided a comprehensive view of all types of secondary metabolites and their occurrence in the formula and all single herbs. These features were annotated by combining MS/MS-based in silico spectral match, manual evaluation of the structural consistency in the FBMN clusters, and taxonomy information. ELSD detection was used as a filter to select the most abundant features. At least one marker per herb was highlighted based on its specificity and abundance. A single large-scale fractionation from the enriched formula enabled the isolation and formal identification of most of them. The obtained markers allowed an improved annotation of associated features by manually propagating this information through the FBMN. These data were incorporated in the high-resolution metabolite profiling of the formula, which highlighted specific series of related components to each individual herb markers. These series of components, named multi-component signatures, may serve to improve the traceability of each herb in the formula. Altogether, the strategy provided highly informative compositional data of the TCM formula and detailed visualizations of the contribution of each herb by FBMN, filtered feature maps, and reconstituted chromatogram traces of all components linked to each specific marker. This comprehensive MS-based analytical workflow allowed a generic and unbiased selection of specific and abundant markers and the identification of multiple related sub-markers. This exploratory approach could serve as a starting point to develop more simple and targeted quality control methods with adapted marker specificity selection criteria to given TCM formula.

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Section: Marker Selectionsupporting

confidence: 53%

A Mass Spectrometry Based Metabolite Profiling Workflow for Selecting Abundant Specific Markers and Their Structurally Related Multi-Component Signatures in Traditional Chinese Medicine Multi‐Herb Formulae

et al. 2020

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“…Due to the diversity of HPLC instrument and chromatographic column, the RRT was difficult to reproduce on different chromatographic systems, as well as the relative correction factor [51] , [52] . Hence, the practical application of RRT method is restricted.…”

Section: Elements Of “Ivarious” Standard Systemmentioning

confidence: 99%

A holistic strategy for quality and safety control of traditional Chinese medicines by the “iVarious” standard system

Chen

Sun

Yuan

et al. 2017

Journal of Pharmaceutical Analysis

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An effective quality control system is the key to ensuring the quality, safety and efficacy of traditional Chinese medicines (TCMs). However, the current quality standard research lacks the top-design and systematic design, mostly based on specific technologies or evaluation methods. To resolve the challenges and questions of quality control of TCMs, a brand-new quality standard system, named “iVarious”, was proposed. The system comprises eight elements in a modular format. Meaning of every element was specifically illustrated via corresponding research instances. Furthermore, frankincense study was taken as an example for demonstrating standards and research process, based on the “iVarious” system. This system highlighted a holistic strategy for effectiveness, security, integrity and systematization of quality and safety control standards of TCMs. The establishment of “iVarious” integrates multi-disciplinary technologies and progressive methods, basis elements and key points of standard construction. The system provides a novel idea and technological demonstration for regulation establishment of TCMs quality standards.

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“…The above methods have been used in pharmacopoeia of many countries, and widely used in related substance test of PC, Chinese medicine feature, fingerprint map, and multi-component determination [18]- [29].…”

Section: Substitute Rsmentioning

confidence: 99%

Progress and Challenges of Reference Standard and Its New Form: Digital Reference Standard

Wang¹,

Sun²,

Feng³

et al. 2016

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Number and quantities of reference standards (RS) needed for the quality control of drugs are increasing, bringing great pressure to the calibration and using company. This manuscript summarized the four generations for the development of RS including physical RS, paper atlas, substitute RS and electronic databases. The advantages and disadvantages of each generation were summarized. The concept of digital RS (DRS) was proposed based on this, and summed up the definition, advantages, and technical architecture of DRS. The 10 characteristics of five aspects of the DRS were discussed including digital, multi-dimension, big data, cloud computing, internet, internet of things, sharing, multi-terminal, intelligence, and compliance certification. Then, the necessity of its formation and application in the medicine holistic quality control of internet plus era was discussed in this manuscript.

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Design of ultraviolet wavelength and standard solution concentrations in relative response factors for simultaneous determination of multi-components with single reference standard in herbal medicines

Cited by 13 publications

References 10 publications

A Mass Spectrometry Based Metabolite Profiling Workflow for Selecting Abundant Specific Markers and Their Structurally Related Multi-Component Signatures in Traditional Chinese Medicine Multi‐Herb Formulae

A Mass Spectrometry Based Metabolite Profiling Workflow for Selecting Abundant Specific Markers and Their Structurally Related Multi-Component Signatures in Traditional Chinese Medicine Multi‐Herb Formulae

A holistic strategy for quality and safety control of traditional Chinese medicines by the “iVarious” standard system

Progress and Challenges of Reference Standard and Its New Form: Digital Reference Standard

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