Design of Ultrasound-Driven Charge Interference Therapy for Wound Infection
Jingwei Zhou,
Xiuru Ji,
Han Wang
et al.
Abstract:Wound infections, especially those caused by pathogenic bacteria, present a considerable public health concern due to associated complications and poor therapeutic outcomes. Herein, we developed antibacterial nanoparticles, namely, PGTP, by coordinating guanidine derivatives with a porphyrin-based sonosensitizer. The synthesized PGTP nanoparticles, characterized by their strong positive charge, effectively disrupted the bacterial biosynthesis process through charge interference, demonstrating efficacy against … Show more
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