Design of ultra-compact multimode interference (MMI) couplers and high efficiency grating couplers in TriPleX platform as part of a photonic based sensor

Gounaridis, Lefteris; Groumas, Panos; Schreuder, Erik; Tsokos, Christos; Mylonas, Elias; Raptakis, Adam; Heideman, René; Avramopoulos, H.; Kouloumentas, Christos

doi:10.1117/12.2510053

Cited by 2 publications

(1 citation statement)

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“…In-coupling of light is achieved by using a two-port grating coupler [ 26 ] ( Figure 9 A in order to trap the light from a VCSEL that is placed on top of the grating structure, while out-coupling of the light from each aMZI sensor output waveguide, towards a photodiode, is realized by means of a single port grating coupler [ 27 ] ( Figure 9 B).…”

Section: Resultsmentioning

confidence: 99%

A Miniature Bio-Photonics Companion Diagnostics Platform for Reliable Cancer Treatment Monitoring in Blood Fluids

Chatzipetrou

Gounaridis

Tsekenis

et al. 2021

Sensors

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In this paper, we present the development of a photonic biosensor device for cancer treatment monitoring as a complementary diagnostics tool. The proposed device combines multidisciplinary concepts from the photonic, nano-biochemical, micro-fluidic and reader/packaging platforms aiming to overcome limitations related to detection reliability, sensitivity, specificity, compactness and cost issues. The photonic sensor is based on an array of six asymmetric Mach Zender Interferometer (aMZI) waveguides on silicon nitride substrates and the sensing is performed by measuring the phase shift of the output signal, caused by the binding of the analyte on the functionalized aMZI surface. According to the morphological design of the waveguides, an improved sensitivity is achieved in comparison to the current technologies (<5000 nm/RIU). This platform is combined with a novel biofunctionalization methodology that involves material-selective surface chemistries and the high-resolution laser printing of biomaterials resulting in the development of an integrated photonics biosensor device that employs disposable microfluidics cartridges. The device is tested with cancer patient blood serum samples. The detection of periostin (POSTN) and transforming growth factor beta-induced protein (TGFBI), two circulating biomarkers overexpressed by cancer stem cells, is achieved in cancer patient serum with the use of the device.

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Section: Resultsmentioning

confidence: 99%