Design of turn-on fluorescent probe for effective detection of Hg2+ by combination of AIEE-active fluorophore and binding site

Zhang, Gaobin; Zhang, Xuanjun; Zhang, Ye; Wang, Hui; Kong, Lin; Tian, Yupeng; Tao, Xutang; Hong, Bo; Yang, Jiaxiang

doi:10.1016/j.snb.2015.06.133

Cited by 39 publications

(9 citation statements)

References 59 publications

(45 reference statements)

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“…Coordination chemistry has been employed for the recognition of Hg 2+ [51][52][53][54][55][56][57][58][59][60]. Structures containing Schiff base, sulfydryl, and imidazole groups show effectiveness for Hg 2+ binding.…”

Section: Mercury Ionsmentioning

confidence: 99%

“…Considering the complexity of living systems, turn-on probes can provide accurate information. By incorporating Schiff base unit, Yang et al designed and synthesized a series of α-cyanostilbene derivatives for Hg 2+ detection [52][53][54]. Hg 2+ binding drove π-π stacking and hydrogen bonding between adjacent probes, which hampered the intramolecular rotation thus caused fluorescence enhancement.…”

Section: Mercury Ionsmentioning

confidence: 99%

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Recent Advances in AIEgens for Metal Ion Biosensing and Bioimaging

Zhong

Huang

et al. 2019

Molecules

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Metal ions play important roles in biological system. Approaches capable of selective and sensitive detection of metal ions in living biosystems provide in situ information and have attracted remarkable research attentions. Among these, fluorescence probes with aggregation-induced emission (AIE) behavior offer unique properties. A variety of AIE fluorogens (AIEgens) have been developed in the past decades for tracing metal ions. This review highlights recent advances (since 2015) in AIE-based sensors for detecting metal ions in biological systems. Major concerns will be devoted to the design principles, sensing performance, and bioimaging applications.

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Section: Mercury Ionsmentioning

confidence: 99%

Section: Mercury Ionsmentioning

confidence: 99%

Recent Advances in AIEgens for Metal Ion Biosensing and Bioimaging

Zhong

Huang

et al. 2019

Molecules

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“…A mixture of 7-(diethylamino)-2-oxo-2Hchromene-3-carbaldehyde 21 (5 mmol, 1.2 g) and malonic acid (7.5 mmol, 0.78 g) were dissolved in 50 mL of acetonitrile, and then added piperidine (3 drops), refluxed for 6 h. The mixture was cooled down to room temperature, and then poured into water. Under vigorously stirring, K 2 CO 3 (aq) was added to adjust the pH to 6.…”

Section: Synthesis Of Lmentioning

confidence: 99%

Two-Photon Active Organotin(IV) Carboxylate Complexes for Visualization of Anticancer Action

Wang¹,

Hu²,

Du³

et al. 2017

ACS Biomater. Sci. Eng.

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It is still a challenge that organotin(IV) carboxylate complexes with high-performance two-photon activity for cancer therapy. At present work, two novel organotin carboxylate complexes LSn1 and LSn2, containing coumarin moiety, were rationally designed for two-photon fluorescent imaging and anticancer purpose. The complexes possessed large two-photon action cross-sections and high quantum yields. Living cells evaluation revealed that complexes LSn1 and LSn2 exhibited good biocompatibility and deeptissue penetration over femtosecond laser with wavelength of 840 nm. Furthermore, the antitumor active and as well as possible mechanism of complexes LSn1 and LSn2 have been investigated systematically. The results indicated that complexes LSn1 and LSn2 could induce apoptotic cell death through a mitochondrial dysfunction and ROS elevation pathway. The present work provides a strategy for rationally designing organotin(IV) carboxylate complexes with two-photon activity and antitumor activity.

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“…In the recent years, there has been significant interest in chromophores that exhibit aggregation‐induced emission (AIE) due to their potential applications as light‐up bioprobes, in analyte detection, sensing, as optoelectronic devices or other functional materials etc . Typically, AIE fluorogens exhibit weak emission in organic solvents but show strong fluorescence in the aggregated state.…”

Section: Introductionmentioning

confidence: 99%

Carbohydrate Tethered Cyanostilbene Fluorogen: Unique Emission and Preferential Protein Binding

2017

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A simple and efficient construction of a water-soluble glycoconjugate bearing a cyanostilbene with glucose pendant and its interaction with proteins is reported. The absorption and fluorescence behavior of this glycoconjugate was investigated in organic solvents, binary-solvent mixtures, water and in the presence of proteins, concanavalin A, bovine serum albumin (BSA) and human serum albumin (HSA). With increase in the solvent polarity, the synthesized derivative exhibited emission quenching but in dioxane-pentane binary mixture, a significant red-shifted emission with substantial Stokes' shift was ob-served. This emission response is attributed to the formation of aggregates and the results were substantiated by scanning electron microscopy (SEM) and dynamic light scattering (DLS) analysis. In the presence of proteins, the fluorophore exhibits moderate binding efficiency and shows synergistic interactions with a combination of hydrophobic and hydrophilic interactions. Circular Dichroism (CD) studies with protein and the fluorophore reveals changes in ellipticity confirming the binding of the fluorophore within the protein domains.

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Design of turn-on fluorescent probe for effective detection of Hg2+ by combination of AIEE-active fluorophore and binding site

Cited by 39 publications

References 59 publications

Recent Advances in AIEgens for Metal Ion Biosensing and Bioimaging

Recent Advances in AIEgens for Metal Ion Biosensing and Bioimaging

Two-Photon Active Organotin(IV) Carboxylate Complexes for Visualization of Anticancer Action

Carbohydrate Tethered Cyanostilbene Fluorogen: Unique Emission and Preferential Protein Binding

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