Abstract:In this work, we propose eigenvalue optimization combined with Lyapunov theory concepts to ensure stability of the Embden-Meyerhof-Parnas pathway, the pentosephosphate pathway, the phosphotransferase system and fermentation reactions of Escherichia coli. We address the design of a metabolic network for the maximization of different metabolite production rates. The first case study focuses on serine production, based on a model that consists of 18 differential equations corresponding to dynamic mass balances fo… Show more
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