Design of solid state bioreactor for industrial applications: An overview to conventional bioreactors

Ashok, Anup; Doriya, Kruthi; Rao, Devulapally Ram Mohan; Kumar, Devarai Santhosh

doi:10.1016/j.bcab.2016.10.014

Cited by 72 publications

(40 citation statements)

References 55 publications

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“…The most important benefit has been greater understanding of the biological system of the microorganism and biological processes in SSF [30]. Research has found that temperature, pH, oxygen, carbon dioxide and heat removal need to be controlled and optimised [11,95]. According to Pandey et al [12,13], SSF bioreactor design should carefully consider design and operating variables, especially aeration transfer, temperature control (including cooling system), effective diffusion of oxygen in gas phase and coefficient for heat transfer through bioreactor wall.…”

Section: Bioreactors For Ssfmentioning

confidence: 99%

“…According to Pandey et al [12,13], SSF bioreactor design should carefully consider design and operating variables, especially aeration transfer, temperature control (including cooling system), effective diffusion of oxygen in gas phase and coefficient for heat transfer through bioreactor wall. In SSF, oxygen transfer can often be inefficient in some designs [11,96]. The problems are complicated, affecting the temperature and the water content of the solid medium, which both need to be, controlled tightly [97,98].…”

Section: Bioreactors For Ssfmentioning

confidence: 99%

“…Thomas et al [10] defined SSF as a three-phase, heterogeneous process, comprising solid, liquid and gaseous phases, which offers potential benefits for the microbial cultivation for bioprocess and products development. In the latest definition, Ashok et al [11] defined SSF as a process involves cultivation of microorganism on solid substrate with minimal moisture content. Whatever the definition, we can understand that SSF is referring to the microbial fermentation, which takes place in the absence or near absence of free water, thus being close to the natural environment to which the selected microorganisms, especially fungi, are naturally adapted.…”

Section: Introductionmentioning

confidence: 99%

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Design Aspects of Solid State Fermentation as Applied to Microbial Bioprocessing

Webb¹

2017

JABB

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Solid state fermentation (SSF) refers to the microbial fermentation, which takes place in the absence or near absence of free water, thus being close to the natural environment to which the selected micro organisms, especially fungi, are naturally adapted. SSF has been used in the world for a long time. This technology is commonly known in the East, for traditional manufacture of fermented foods, and in the west, for mould-ripened cheese. It can be defined as a system, in which the growth of selected microorganism(s) occurs on solid materials with low moisture contents and has been identified as a potentially important methodology and technique in biotechnology. Nowadays, SSF is an economically viable, practically acceptable technology for large-scale bioconversion and biodegradation processes. Development of sustainable SSF and bioprocess technology is an emerging, multidisciplinary field with possible application to the production of enzymes, chemicals, bioethanol and pharmaceuticals. SSF offers many advantages over conventional submerged fermentation (SMF) such as, simple and inexpensive substrates, elimination of the need for solubilisation of nutrient from within solid substrates, elimination of the need for rigorous control of many parameters during fermentation, product yields are mostly higher, lower energy requirements, produce less waste water, no foam generation and relatively easy recovery of end products. SSF provides flexibility in terms of the raw materials to be used and their capability to produce various value-added products. Keywords:

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Section: Bioreactors For Ssfmentioning

confidence: 99%

Section: Bioreactors For Ssfmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Design Aspects of Solid State Fermentation as Applied to Microbial Bioprocessing

Webb¹

2017

JABB

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“…Problems associated with this process include high cost of equipment, media, and higher probability of contamination. The traditional and emerging field of solid-state fermentation (SSF) has enabled the better production of a wide range of enzymes and metabolites which require less energy than SmF (Pandey 2003;Viniegra-González et al 2003;Ashok et al 2017). The credibility of solid-state fermentation (SSF) for production of enzyme has gained importance in developing countries (Singhania et al 2009).…”

Section: Introductionmentioning

confidence: 99%

“…SSF also offers other advantages including resistance to contamination and ease of product extraction, and provides a better opportunity for the biosynthesis of low-volumehigh-cost products. This is achieved by using low cost accessible agro-industrial residues as solid substrates, which provide both anchorage and nutrient source to microbial cells (Krishna 2005;Ashok et al 2017). These agricultural residues are being generated in huge quantities in developing countries and problems associated with their disposal is also an important environmental concern.…”

Section: Introductionmentioning

confidence: 99%

Production and optimization of lipase using Aspergillus niger MTCC 872 by solid-state fermentation

et al. 2019

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Background: Lipases are serine hydrolases that degrade triglycerides, an attribute that treasures wide applications in biodiesel production, detergent, chemical industries, etc. The most sought after the application is in the high quality and economical production of biodiesel under mild reaction conditions and simplified product separation. For the said application, fungal lipases are ideal catalysts that could effectively catalyze esterification and transesterification reactions with their specific ability to release fatty acids from 1, 3 positions of acylglycerols. Results: In the present work, to facilitate bulk synthesis, lipase production using Aspergillus niger MTCC 872 was studied by solid-state fermentation (SSF). The chosen fungal strain was evaluated for lipase production using a mixture of agroindustrial substrates viz. rice husk, cottonseed cake, and red gram husk in various combinations at flask level. Tri-substrate mixture (rice husk, cottonseed cake, and red gram husk) combined in the ratio of 2:1:1 has shown the maximum lipase activity 28.19 U/gds at optimum cultivation conditions of temperature 40°C, moisture content 75% (v/w), pH 6.0 and initial spore concentration of 5.4 million spores per mL. Further studies were performed for scale-up of lipase from flask level to lab scale using tray fermenter. Lipase activity was found to be 24.38 U/gds and 21.62 U/gds for 100 g and 1000 g substrate respectively. Conclusion: This is the first report on the production of lipase from Aspergillus niger MTCC 872 using tri-substrate mixture of rice husk (RH), cottonseed cake (CSC), and red gram husk (RGH). Moreover, comparison between individual, binary, and tri-substrate mixture was carried out for which the highest lipase activity was observed for tri-substrate mixture. In addition, comparable results were found when scale-up was performed using tray fermenter. Thus, the current work signifies usage of agro-industrial residues as substrates for enzyme production by solid-state fermentation process as an effective alternative to submerged fermentation for industrial applications.

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Sustainable Production of Biosurfactants and Their Applications

Marcelino

Gonçalves

Jiménez

et al. 2020

Lignocellulosic Biorefining Technologies

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Design of solid state bioreactor for industrial applications: An overview to conventional bioreactors

Cited by 72 publications

References 55 publications

Design Aspects of Solid State Fermentation as Applied to Microbial Bioprocessing

Design Aspects of Solid State Fermentation as Applied to Microbial Bioprocessing

Production and optimization of lipase using Aspergillus niger MTCC 872 by solid-state fermentation

Sustainable Production of Biosurfactants and Their Applications

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