Design of selective cell migration biomaterials and their applications for tissue regeneration

Yang, Chen; Yang, Ying; Qiu, Dong

doi:10.1007/s10853-020-05537-y

Cited by 10 publications

(5 citation statements)

References 112 publications

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“…Cell migration is a complex dynamic process, which plays an important role in tissue regeneration and repairing. A tissue regenerative biomaterial substrate should provide the basic supporting for the growth of cells and their recruitment and migration, since cell directional migration to the wound site is a crucial prerequisite in tissue regeneration [ 19 ]. Bright field microscopy images show migration of hUCMSCs cells after scratching at time 0 and after 3, 5 and 24 h of incubation with the control and formulations.…”

Section: Resultsmentioning

confidence: 99%

Effect of Hyaluronic Acid and Mesenchymal Stem Cells Secretome Combination in Promoting Alveolar Regeneration

Sala

Longobardo

Lista

et al. 2023

IJMS

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Pharmacological therapies in lung diseases are nowadays useful in reducing the symptomatology of lung injury. However, they have not yet been translated to effective treatment options able to restore the lung tissue damage. Cell-therapy based on Mesenchymal Stem Cells (MSCs) is an attractive, as well as new therapeutic approach, although some limitations can be ascribed for therapeutic use, such as tumorigenicity and immune rejection. However, MSCs have the capacity to secrete multiple paracrine factors, namely secretome, capable of regulating endothelial and epithelial permeability, decrease inflammation, enhancing tissue repair, and inhibiting bacterial growth. Furthermore, Hyaluronic Acid (HA) has been demonstrated to have particularly efficacy in promoting the differentiation of MSCs in Alveolar type II (ATII) cells. In this frame, the combination of HA and secretome to achieve the lung tissue regeneration has been investigated for the first time in this work. Overall results showed how the combination of HA (low and medium molecular weight HA) plus secretome could enhance MSCs differentiation in ATII cells (SPC marker expression of about 5 ng/mL) compared to the only HA or secretome solutions alone (SPC about 3 ng/mL, respectively). Likewise, cell viability and cell rate of migration were reported to be improved for HA and secretome blends, indicating an interesting potentiality of such systems for lung tissue repair. Moreover, an anti-inflammatory profile has been revealed when dealing with HA and secretome mixtures. Therefore, these promising results can allow important advance in the accomplishment of the future therapeutic approach in respiratory diseases, up to date still missing.

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Section: Resultsmentioning

confidence: 99%

Effect of Hyaluronic Acid and Mesenchymal Stem Cells Secretome Combination in Promoting Alveolar Regeneration

Sala

Longobardo

Lista

et al. 2023

IJMS

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“…The interactions of YIGSR and integrin promote ECM connection which is critically important for HUVEC microenvironments [38]. Moreover, the immobilization of YIGSR on ECM can strikingly enhance HUVEC proliferations and cell movements [39]. Expression level of this receptor is associated with cell proliferation and migration.…”

Section: Discussionmentioning

confidence: 99%

Regulatory effects of laminin derived peptide on microtissue formation for tissue engineered scaffold-free constructs

Çevik

Ordek

Karaman

2022

The European Research Journal

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Objectives: Vascularization is an important stage for tissues and organs. The vascular network is succeeded by the attachment, spreading, proliferation of endothelial cells, and the completion of endothelialization. Endothelization can be mediated by laminin-derived peptides on microtissues. It is known that laminin-derived Tyr-Ile-Gly-Ser-Arg (YIGSR) peptide contributes to endothelial microtissue formation by promoting increased adhesion and proliferation of endothelial cells. This study aims to determine the efficacy of the laminin-derived YIGSR peptide in Human Umbilicial Vein Endothelial Cell (HUVEC) scaffold free microtissues (SFMs). Methods: After solid phase synthesis of YIGSR, microtissues were formed as SFMs. SFMs were cultured with 0 mM (control group), 1.5 mM and 3 mM YIGSR peptide. Diameters and viability analysis of HUVEC SFMs were performed on the 1 st , 4 th and 7 th days. Results: The diameters of control SFMs group decreased day by day. Diameters of 3 mM YIGSR SFMs increased on the 1 st and 4 th days but significantly decreased on the 7 th day. On the other hand, 1.5 mM YIGSR had a tendency on tissue formation because of increased diameter. As a result of the viability, YIGSR peptide increased cell viability. Conclusions: It has been determined that 1.5 mM YIGSR is the optimum amount for enlargement and viability of HUVEC SFMs. The concentration has contributed to proliferation and viability of endothelial SFMs. Thus, 1.5 mM YIGSR has been found as the most promising peptide concentration for increasing vascularization.

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“…The biomedical polymers used for tissue repair and regeneration can be divided into two classifications: ex vivo and in situ. The in situ approach, also defined as endogenous regeneration, requires biochemical or biophysical factors in combination with self-adaptive and bioresponsive materials [408], which can modulate or respond to multiple cell behaviors such as directional cell migration [409,410], selective cell adhesion [411], extracellular signal pathways [412], and intracellular gene programming [413].…”

Section: Biomedical Polymers For Regenerative Medicine 61 Biomedical ...mentioning

confidence: 99%

Biomedical polymers: synthesis, properties, and applications

Chen

et al. 2022

Sci. China Chem.

102

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Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation.

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Design of selective cell migration biomaterials and their applications for tissue regeneration

Cited by 10 publications

References 112 publications

Effect of Hyaluronic Acid and Mesenchymal Stem Cells Secretome Combination in Promoting Alveolar Regeneration

Effect of Hyaluronic Acid and Mesenchymal Stem Cells Secretome Combination in Promoting Alveolar Regeneration

Regulatory effects of laminin derived peptide on microtissue formation for tissue engineered scaffold-free constructs

Biomedical polymers: synthesis, properties, and applications

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